A novel function of karyopherin beta 3 associated with apolipoprotein A-I secretion SCIE SCOPUS KCI

DC Field Value Language
dc.contributor.author Chung, Kyung Min -
dc.contributor.author Cha, Sun-Shin -
dc.contributor.author Jang, Sung Key -
dc.date.accessioned 2020-04-20T10:40:24Z -
dc.date.available 2020-04-20T10:40:24Z -
dc.date.created 2020-01-28 -
dc.date.issued 2008-09-30 -
dc.identifier.issn 1016-8478 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/4448 -
dc.description.abstract Human karyopherin beta 3, highly homologous to a yeast protein secretion enhancer (PSE1), has often been reported to be associated with a mediator of a nucleocytoplasmic transport pathway. Previously, we showed that karyopherin beta 3 complemented the PSE1 and KAP123 double mutant. Our research suggested that karyopherin beta 3 has an evolutionary function similar to that of yeast PSE1 and/or KAP 123. In this study, we performed yeast two-hybrid screening to find a protein which would interact with karyopherin beta 3 and identified apolipoprotein A-I (apo A-I), a secretion protein with a primary function in cholesterol transport. By using in vitro binding assay, coimmunoprecipitation, and colocalization studies, we defined an interaction between karyopherin beta 3 and apo A-I. In addition, overexpression of karyopherin beta 3 significantly increased apo A-I secretion. These results suggest that karyopherin beta 3 plays a crucial role in apo A-I secretion. These findings may be relevant to the study of a novel function of karyopherin beta 3 and coronary artery diseases associated with apo A-I. -
dc.description.uri 1 -
dc.language English -
dc.publisher KOREAN SOC MOLECULAR & CELLULAR BIOLOGY -
dc.subject NUCLEAR IMPORT RECEPTORS -
dc.subject MINOR CAPSID PROTEIN -
dc.subject ENDOPLASMIC-RETICULUM -
dc.subject SACCHAROMYCES-CEREVISIAE -
dc.subject RIBOSOMAL-PROTEINS -
dc.subject CHOLESTEROL EFFLUX -
dc.subject MAMMALIAN-CELLS -
dc.subject PORE COMPLEX -
dc.subject TRANSPORT -
dc.subject INTERACTS -
dc.title A novel function of karyopherin beta 3 associated with apolipoprotein A-I secretion -
dc.type Article -
dc.citation.endPage 298 -
dc.citation.startPage 291 -
dc.citation.title MOLECULES AND CELLS -
dc.citation.volume 26 -
dc.citation.number 3 -
dc.identifier.bibliographicCitation MOLECULES AND CELLS, v.26, no.3, pp.291 - 298 -
dc.identifier.scopusid 2-s2.0-55249089740 -
dc.identifier.wosid 000259782200011 -
dc.type.docType Article -
dc.identifier.kciid ART001278404 -
dc.description.journalClass 1 -
dc.subject.keywordPlus NUCLEAR IMPORT RECEPTORS -
dc.subject.keywordPlus MINOR CAPSID PROTEIN -
dc.subject.keywordPlus ENDOPLASMIC-RETICULUM -
dc.subject.keywordPlus SACCHAROMYCES-CEREVISIAE -
dc.subject.keywordPlus RIBOSOMAL-PROTEINS -
dc.subject.keywordPlus CHOLESTEROL EFFLUX -
dc.subject.keywordPlus MAMMALIAN-CELLS -
dc.subject.keywordPlus PORE COMPLEX -
dc.subject.keywordPlus TRANSPORT -
dc.subject.keywordPlus INTERACTS -
dc.subject.keywordAuthor apolipoprotein A-I -
dc.subject.keywordAuthor coronary artery diseases -
dc.subject.keywordAuthor karyopherin beta 3 -
dc.subject.keywordAuthor PSE1 -
dc.subject.keywordAuthor secretion enhancer -
dc.relation.journalWebOfScienceCategory Biochemistry & Molecular Biology -
dc.relation.journalWebOfScienceCategory Cell Biology -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.description.journalRegisteredClass kci -
dc.relation.journalResearchArea Biochemistry & Molecular Biology -
dc.relation.journalResearchArea Cell Biology -
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