New Glycosylated Secondary Metabolites from Marine-Derived Bacteria SCIE SCOPUS

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Title
New Glycosylated Secondary Metabolites from Marine-Derived Bacteria
Author(s)
Anh, Cad Van; Kang, Jong Soon; Lee, Hwa Sun; Trinh, Phan Thi Hoai; Heo, Chang Su; Shin, Hee Jae
KIOST Author(s)
ANH, CAO VAN(Cao Van Anh)Lee, Hwa Sun(이화선)Heo, Chang Su(허창수)Shin, Hee Jae(신희재)
Alternative Author(s)
Cao Van Anh; 이화선; 허창수; 신희재
Publication Year
2022-07
Abstract
Three new glycosylated secondary metabolites, including a new indole alkaloid, pityriacitrin D (1), and two new trehalose lipids (2 and 3), together with three known compounds (4–6) were isolated from two marine-derived bacterial strains, Bacillus siamensis 168CLC-66.1 and Tsukamurella pseudospumae IV19-045. The structures of 1–3 were determined by extensive analysis and comparison of their spectroscopic data with literature values. The absolute configurations of sugar moieties were determined by chemical derivatization followed by LC-MS analysis. Cytotoxicity of 1–3 against six cancer cell lines was evaluated by SRB assay, and 1 showed moderate activity against all the tested cell lines with GI50 values ranging from 8.0 to 10.9 µM.
ISSN
1660-3397
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/43101
DOI
10.3390/md20070464
Bibliographic Citation
Marine Drugs, v.20, no.7, 2022
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
marine-derived bacteria; glycosides; pityriacitrin; trehalose lipid; cytotoxicity
Type
Article
Language
English
Document Type
Article
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
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