Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model SCIE SCOPUS KCI

Cited 10 time in WEB OF SCIENCE Cited 11 time in Scopus
Title
Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model
Author(s)
Seo, Jong Bae; Jeong, Jae-Yeon; Park, Jae Young; Jun, Eun Mi; Lee, Sang-Ik; Choe, Sung Sik; Park, Do-Yang; Choi, Eun-Wook; Seen, Dong-Seung; Lim, Jong-Soon; Lee, Tae Gyu
Publication Year
2012-01-31
Abstract
The fruit of Terminalia chebula Retzius has been used as a panacea in India and Southeast Asia but its biological activities have not been fully elucidated. Here we report anti-arthritic and analgesic effect of NDI10218, a standardized ethanol extract of Terminalia chebula, on collagen-induced arthritis and acetic acid-induced writhing model, respectively. Arthritis was induced in DBA/1J mice by immunizing bovine type II collagen and mice were treated with NDI10218 daily for 5 weeks after the onset of the disease. NDI10218 reduced the arthritis index and blocked the synovial hyperplasia in a dose-dependent manner. The serum levels of pro-inflammatory cytokines INF-alpha, IL-6, and IL-1 beta were significantly reduced in mice treated with NDI10218. Production of the inflammatory IL-17, but not immunosuppressive IL-10, was also inhibited in splenocytes isolated from NDI10218-treated arthritis mice. Administration of NDI10218 markedly decreased the number of T cell subpopulations in the regional lymph nodes of the arthritis mice. Finally, NDI10218 reduced the number of abdominal contractions in acetic acid-induced writhing model, suggesting an analgesic effect of this extract. Taken together, these results suggest that NDI10218 can be a new therapeutic candidate for the treatment of rheumatoid arthritis.
ISSN
1976-9148
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3641
DOI
10.4062/biomolther.2012.20.1.104
Bibliographic Citation
BIOMOLECULES & THERAPEUTICS, v.20, no.1, pp.104 - 112, 2012
Publisher
KOREAN SOC APPLIED PHARMACOLOGY
Subject
INDIAN MEDICINAL-PLANTS; COLLAGEN-INDUCED ARTHRITIS; REGULATORY T-CELLS; RHEUMATOID-ARTHRITIS; AQUEOUS EXTRACT; IN-VITRO; RATS; INFLAMMATION; ACID; METHOTREXATE
Keywords
Terminalia chebula; Arthritis; Pain; Anti-inflammatory; Analgesic
Type
Article
Language
English
Document Type
Article
Publisher
KOREAN SOC APPLIED PHARMACOLOGY
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