Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model SCIE SCOPUS KCI
DC Field | Value | Language |
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dc.contributor.author | Seo, Jong Bae | - |
dc.contributor.author | Jeong, Jae-Yeon | - |
dc.contributor.author | Park, Jae Young | - |
dc.contributor.author | Jun, Eun Mi | - |
dc.contributor.author | Lee, Sang-Ik | - |
dc.contributor.author | Choe, Sung Sik | - |
dc.contributor.author | Park, Do-Yang | - |
dc.contributor.author | Choi, Eun-Wook | - |
dc.contributor.author | Seen, Dong-Seung | - |
dc.contributor.author | Lim, Jong-Soon | - |
dc.contributor.author | Lee, Tae Gyu | - |
dc.date.accessioned | 2020-04-20T06:55:42Z | - |
dc.date.available | 2020-04-20T06:55:42Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2012-01-31 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/3641 | - |
dc.description.abstract | The fruit of Terminalia chebula Retzius has been used as a panacea in India and Southeast Asia but its biological activities have not been fully elucidated. Here we report anti-arthritic and analgesic effect of NDI10218, a standardized ethanol extract of Terminalia chebula, on collagen-induced arthritis and acetic acid-induced writhing model, respectively. Arthritis was induced in DBA/1J mice by immunizing bovine type II collagen and mice were treated with NDI10218 daily for 5 weeks after the onset of the disease. NDI10218 reduced the arthritis index and blocked the synovial hyperplasia in a dose-dependent manner. The serum levels of pro-inflammatory cytokines INF-alpha, IL-6, and IL-1 beta were significantly reduced in mice treated with NDI10218. Production of the inflammatory IL-17, but not immunosuppressive IL-10, was also inhibited in splenocytes isolated from NDI10218-treated arthritis mice. Administration of NDI10218 markedly decreased the number of T cell subpopulations in the regional lymph nodes of the arthritis mice. Finally, NDI10218 reduced the number of abdominal contractions in acetic acid-induced writhing model, suggesting an analgesic effect of this extract. Taken together, these results suggest that NDI10218 can be a new therapeutic candidate for the treatment of rheumatoid arthritis. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | - |
dc.subject | INDIAN MEDICINAL-PLANTS | - |
dc.subject | COLLAGEN-INDUCED ARTHRITIS | - |
dc.subject | REGULATORY T-CELLS | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | AQUEOUS EXTRACT | - |
dc.subject | IN-VITRO | - |
dc.subject | RATS | - |
dc.subject | INFLAMMATION | - |
dc.subject | ACID | - |
dc.subject | METHOTREXATE | - |
dc.title | Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model | - |
dc.type | Article | - |
dc.citation.endPage | 112 | - |
dc.citation.startPage | 104 | - |
dc.citation.title | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.volume | 20 | - |
dc.citation.number | 1 | - |
dc.contributor.alternativeName | 정재연 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES & THERAPEUTICS, v.20, no.1, pp.104 - 112 | - |
dc.identifier.doi | 10.4062/biomolther.2012.20.1.104 | - |
dc.identifier.scopusid | 2-s2.0-84863182675 | - |
dc.identifier.wosid | 000300469100014 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | INDIAN MEDICINAL-PLANTS | - |
dc.subject.keywordPlus | COLLAGEN-INDUCED ARTHRITIS | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | AQUEOUS EXTRACT | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | METHOTREXATE | - |
dc.subject.keywordAuthor | Terminalia chebula | - |
dc.subject.keywordAuthor | Arthritis | - |
dc.subject.keywordAuthor | Pain | - |
dc.subject.keywordAuthor | Anti-inflammatory | - |
dc.subject.keywordAuthor | Analgesic | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |