DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling SCIE SCOPUS

Cited 50 time in WEB OF SCIENCE Cited 55 time in Scopus
Title
DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling
Author(s)
Kim, Jung-Min; Shin, Hong-In; Cha, Sun-Shin; Lee, Chang Sup; Hong, Bok Sil; Lim, Seyoung; Jang, Hyun-Jun; Kim, Jaeyoon; Yang, Yong Ryoul; Kim, Yun-Hee; Yun, Sanguk; Rijal, Girdhari; Lee-Kwon, Whaseon; Seo, Jeong Kon; Gho, Yong Song; Ryu, Sung Ho; Hur, Eun-Mi; Suh, Pann-Ghill
Alternative Author(s)
차선신
Publication Year
2012-12
Abstract
Communication between osteoblasts and endothelial cells is essential for bone fracture repair, but the molecular identities of such communicating factors are not well defined. Here we identify DJ-1 as a novel mediator of the cross-talk between osteoblasts and endothelial cells through an unbiased screening of molecules secreted from human mesenchymal stem cells during osteogenesis. We show that DJ-1 stimulates the differentiation of human mesenchymal stem cells to osteoblasts and that DJ-1 induces angiogenesis in endothelial cells through activation of fibroblast growth factor receptor-1 signalling. In a rodent model of bone fracture repair, extracellular application of DJ-1 enhances bone regeneration in vivo by stimulating the formation of blood vessels and new bones. Both these effects are blocked by antagonizing fibroblast growth factor receptor-1 signalling. These findings uncover previously undefined extracellular roles of DJ-1 to promote angiogenesis and osteogenesis, suggesting DJ-1 may have therapeutic potential to stimulate bone regeneration.
ISSN
2041-1723
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3419
DOI
10.1038/ncomms2313
Bibliographic Citation
NATURE COMMUNICATIONS, v.3, 2012
Publisher
NATURE PUBLISHING GROUP
Subject
ENDOTHELIAL-GROWTH-FACTOR; BONE-FORMATION; PARKINSONS-DISEASE; PROTEIN-KINASE; CELLS; VEGF; EXPRESSION; PATHWAY; DEFECT; IDENTIFICATION
Type
Article
Language
English
Document Type
Article
Publisher
NATURE PUBLISHING GROUP
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