DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling SCIE SCOPUS

DC Field Value Language Kim, Jung-Min - Shin, Hong-In - Cha, Sun-Shin - Lee, Chang Sup - Hong, Bok Sil - Lim, Seyoung - Jang, Hyun-Jun - Kim, Jaeyoon - Yang, Yong Ryoul - Kim, Yun-Hee - Yun, Sanguk - Rijal, Girdhari - Lee-Kwon, Whaseon - Seo, Jeong Kon - Gho, Yong Song - Ryu, Sung Ho - Hur, Eun-Mi - Suh, Pann-Ghill - 2020-04-20T06:40:18Z - 2020-04-20T06:40:18Z - 2020-01-28 - 2012-12 -
dc.identifier.issn 2041-1723 -
dc.identifier.uri -
dc.description.abstract Communication between osteoblasts and endothelial cells is essential for bone fracture repair, but the molecular identities of such communicating factors are not well defined. Here we identify DJ-1 as a novel mediator of the cross-talk between osteoblasts and endothelial cells through an unbiased screening of molecules secreted from human mesenchymal stem cells during osteogenesis. We show that DJ-1 stimulates the differentiation of human mesenchymal stem cells to osteoblasts and that DJ-1 induces angiogenesis in endothelial cells through activation of fibroblast growth factor receptor-1 signalling. In a rodent model of bone fracture repair, extracellular application of DJ-1 enhances bone regeneration in vivo by stimulating the formation of blood vessels and new bones. Both these effects are blocked by antagonizing fibroblast growth factor receptor-1 signalling. These findings uncover previously undefined extracellular roles of DJ-1 to promote angiogenesis and osteogenesis, suggesting DJ-1 may have therapeutic potential to stimulate bone regeneration. -
dc.description.uri 1 -
dc.language English -
dc.subject BONE-FORMATION -
dc.subject PROTEIN-KINASE -
dc.subject CELLS -
dc.subject VEGF -
dc.subject EXPRESSION -
dc.subject PATHWAY -
dc.subject DEFECT -
dc.title DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling -
dc.type Article -
dc.citation.title NATURE COMMUNICATIONS -
dc.citation.volume 3 -
dc.contributor.alternativeName 차선신 -
dc.identifier.bibliographicCitation NATURE COMMUNICATIONS, v.3 -
dc.identifier.doi 10.1038/ncomms2313 -
dc.identifier.scopusid 2-s2.0-84871775091 -
dc.identifier.wosid 000316356700063 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus ENDOTHELIAL-GROWTH-FACTOR -
dc.subject.keywordPlus BONE-FORMATION -
dc.subject.keywordPlus PARKINSONS-DISEASE -
dc.subject.keywordPlus PROTEIN-KINASE -
dc.subject.keywordPlus CELLS -
dc.subject.keywordPlus VEGF -
dc.subject.keywordPlus EXPRESSION -
dc.subject.keywordPlus PATHWAY -
dc.subject.keywordPlus DEFECT -
dc.subject.keywordPlus IDENTIFICATION -
dc.relation.journalWebOfScienceCategory Multidisciplinary Sciences -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Science & Technology - Other Topics -
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