Isolation of functional marine natural products from two tropical marine sponges

Title
Isolation of functional marine natural products from two tropical marine sponges
Author(s)
한샘; 이연주
KIOST Author(s)
Lee, Yeon Ju(이연주)
Alternative Author(s)
한샘; 이연주
Publication Year
2012-05-24
Abstract
Tropical marine sponges are known to be one of the richest source of biologically active compounds, which prompted us to prepare the library of extracts of sponges from federated states of Micronesia and examine the biological activity of those. One of the results which seemed to be promising was that of adenosine receptor (AR) binding activity, which have a broad therapeutic potential such as sedarive, cardioprotective agent, modulator of renal fuction and etc. Chemical analysis of the selected sponge led to the isolation of known halisulfates, of which the AR binding activities are under investigations. Another sponge, identified as Chondrosia sp., which also came from Micronesia, was found out to contain psammaplysin analogs, which is known to exhibit potent antimalarial activities, by proton NMR of the crude extract. Throught the chemical investigations, psammplysin and bromotyrosine derivatives with novel structures and high cancer cell growth inhibitory activity were obtained.of those. One of the results which seemed to be promising was that of adenosine receptor (AR) binding activity, which have a broad therapeutic potential such as sedarive, cardioprotective agent, modulator of renal fuction and etc. Chemical analysis of the selected sponge led to the isolation of known halisulfates, of which the AR binding activities are under investigations. Another sponge, identified as Chondrosia sp., which also came from Micronesia, was found out to contain psammaplysin analogs, which is known to exhibit potent antimalarial activities, by proton NMR of the crude extract. Throught the chemical investigations, psammplysin and bromotyrosine derivatives with novel structures and high cancer cell growth inhibitory activity were obtained.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/27779
Bibliographic Citation
International Symposium on Marine Bioprospecting, pp.9, 2012
Publisher
Korea
Type
Conference
Language
English
Publisher
Korea
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