Isolation of functional marine natural products from two tropical marine sponges

DC Field Value Language
dc.contributor.author 한샘 -
dc.contributor.author 이연주 -
dc.date.accessioned 2020-07-16T12:51:12Z -
dc.date.available 2020-07-16T12:51:12Z -
dc.date.created 2020-02-11 -
dc.date.issued 2012-05-24 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/27779 -
dc.description.abstract Tropical marine sponges are known to be one of the richest source of biologically active compounds, which prompted us to prepare the library of extracts of sponges from federated states of Micronesia and examine the biological activity of those. One of the results which seemed to be promising was that of adenosine receptor (AR) binding activity, which have a broad therapeutic potential such as sedarive, cardioprotective agent, modulator of renal fuction and etc. Chemical analysis of the selected sponge led to the isolation of known halisulfates, of which the AR binding activities are under investigations. Another sponge, identified as Chondrosia sp., which also came from Micronesia, was found out to contain psammaplysin analogs, which is known to exhibit potent antimalarial activities, by proton NMR of the crude extract. Throught the chemical investigations, psammplysin and bromotyrosine derivatives with novel structures and high cancer cell growth inhibitory activity were obtained.of those. One of the results which seemed to be promising was that of adenosine receptor (AR) binding activity, which have a broad therapeutic potential such as sedarive, cardioprotective agent, modulator of renal fuction and etc. Chemical analysis of the selected sponge led to the isolation of known halisulfates, of which the AR binding activities are under investigations. Another sponge, identified as Chondrosia sp., which also came from Micronesia, was found out to contain psammaplysin analogs, which is known to exhibit potent antimalarial activities, by proton NMR of the crude extract. Throught the chemical investigations, psammplysin and bromotyrosine derivatives with novel structures and high cancer cell growth inhibitory activity were obtained. -
dc.description.uri 1 -
dc.language English -
dc.publisher Korea -
dc.relation.isPartOf International Symposium on Marine Bioprospecting -
dc.title Isolation of functional marine natural products from two tropical marine sponges -
dc.type Conference -
dc.citation.conferencePlace KO -
dc.citation.endPage 9 -
dc.citation.startPage 9 -
dc.citation.title International Symposium on Marine Bioprospecting -
dc.contributor.alternativeName 한샘 -
dc.contributor.alternativeName 이연주 -
dc.identifier.bibliographicCitation International Symposium on Marine Bioprospecting, pp.9 -
dc.description.journalClass 1 -
Appears in Collections:
Marine Resources Research Division > Marine Biotechnology Research Center > 2. Conference Papers
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