파킨슨병 원인 단백질인 DJ-1의 3가지 구조 상태

Title
파킨슨병 원인 단백질인 DJ-1의 3가지 구조 상태
Alternative Title
Three Structural Phases of the Parkinson
Author(s)
차선신
Alternative Author(s)
차선신
Publication Year
2012-10-12
Abstract
DJ-1 is engaged in diverse cellular processes including cellular transformation, control of protein-RNA interaction, modulation of androgen receptor, antioxidative response, sperm fertilization, and autosomal recessive early-onset parkinsonism. Although it is not clear how DJ-1 participates in various cellular processes, structural alteration can be one of the molecular bases underlying the functional feature of DJ-1. DJ-1 forms filamentous aggregates in the presence of inorganic phosphate whereas DJ-1 normally exists as a homodimeric protein. In addition, the deletion of C-terminal fifteen residues leads to the oligomerization of DJ-1. Here, we depict the details of the three distinct structural phases of DJ-1 revealed by X-ray crystallography and electron microscopy, and investigate their functional consequences.nsonism. Although it is not clear how DJ-1 participates in various cellular processes, structural alteration can be one of the molecular bases underlying the functional feature of DJ-1. DJ-1 forms filamentous aggregates in the presence of inorganic phosphate whereas DJ-1 normally exists as a homodimeric protein. In addition, the deletion of C-terminal fifteen residues leads to the oligomerization of DJ-1. Here, we depict the details of the three distinct structural phases of DJ-1 revealed by X-ray crystallography and electron microscopy, and investigate their functional consequences.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/27536
Bibliographic Citation
2012 한국분자세포생물학회 정기 학술대회, pp.60, 2012
Publisher
한국분자세포생물학회
Type
Conference
Language
English
Publisher
한국분자세포생물학회
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