파킨슨병 원인 단백질인 DJ-1의 3가지 구조 상태
DC Field | Value | Language |
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dc.contributor.author | 차선신 | - |
dc.date.accessioned | 2020-07-16T11:50:33Z | - |
dc.date.available | 2020-07-16T11:50:33Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2012-10-12 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/27536 | - |
dc.description.abstract | DJ-1 is engaged in diverse cellular processes including cellular transformation, control of protein-RNA interaction, modulation of androgen receptor, antioxidative response, sperm fertilization, and autosomal recessive early-onset parkinsonism. Although it is not clear how DJ-1 participates in various cellular processes, structural alteration can be one of the molecular bases underlying the functional feature of DJ-1. DJ-1 forms filamentous aggregates in the presence of inorganic phosphate whereas DJ-1 normally exists as a homodimeric protein. In addition, the deletion of C-terminal fifteen residues leads to the oligomerization of DJ-1. Here, we depict the details of the three distinct structural phases of DJ-1 revealed by X-ray crystallography and electron microscopy, and investigate their functional consequences.nsonism. Although it is not clear how DJ-1 participates in various cellular processes, structural alteration can be one of the molecular bases underlying the functional feature of DJ-1. DJ-1 forms filamentous aggregates in the presence of inorganic phosphate whereas DJ-1 normally exists as a homodimeric protein. In addition, the deletion of C-terminal fifteen residues leads to the oligomerization of DJ-1. Here, we depict the details of the three distinct structural phases of DJ-1 revealed by X-ray crystallography and electron microscopy, and investigate their functional consequences. | - |
dc.description.uri | 2 | - |
dc.language | English | - |
dc.publisher | 한국분자세포생물학회 | - |
dc.relation.isPartOf | 2012 한국분자세포생물학회 정기 학술대회 | - |
dc.title | 파킨슨병 원인 단백질인 DJ-1의 3가지 구조 상태 | - |
dc.title.alternative | Three Structural Phases of the Parkinson | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 60 | - |
dc.citation.startPage | 60 | - |
dc.citation.title | 2012 한국분자세포생물학회 정기 학술대회 | - |
dc.contributor.alternativeName | 차선신 | - |
dc.identifier.bibliographicCitation | 2012 한국분자세포생물학회 정기 학술대회, pp.60 | - |
dc.description.journalClass | 2 | - |