열대해면 Reniochalina sp.유래 신규 세포독성 아세틸레닉 알코올

Title
열대해면 Reniochalina sp.유래 신규 세포독성 아세틸레닉 알코올
Alternative Title
New cytotoxic acetylenic alcohols from the tropical sponge Reniochalina sp.
Author(s)
박승일; 이종석; 이연주; 신희재; 원호식; 이희승
KIOST Author(s)
Lee, Jong Seok(이종석)Lee, Yeon Ju(이연주)Shin, Hee Jae(신희재)Lee, Hyi Seung(이희승)
Alternative Author(s)
박승일; 이종석; 이연주; 신희재; 이희승
Publication Year
2014-04-22
Abstract
In the course of our search for biologically active compounds from tropical marine invertebrate, we found bioactive compounds from the tropical sponge Reniochalina sp. collected in Chuuk State, Federated States of Micronesia. Some of these compounds displayed significant growth inhibition against human tumor cell line. Bioassy-guided separation of the crude extracts using various chromatographic techniques yielded five new metabolites along with ghree known metabolites which belong to the class of acetylenic compounds from the extracts of Reniochalina sp. Their structures were elucidated on the basis of mass spectrometry and 2D NMR spectroscopic data. The absolute stereochemistry of new compounds was determined by chemical transformations and the MOsher methods. Some of these compounds exhibited significant growth inhibitory effect against human leukemia cell-line K-562.compounds displayed significant growth inhibition against human tumor cell line. Bioassy-guided separation of the crude extracts using various chromatographic techniques yielded five new metabolites along with ghree known metabolites which belong to the class of acetylenic compounds from the extracts of Reniochalina sp. Their structures were elucidated on the basis of mass spectrometry and 2D NMR spectroscopic data. The absolute stereochemistry of new compounds was determined by chemical transformations and the MOsher methods. Some of these compounds exhibited significant growth inhibitory effect against human leukemia cell-line K-562.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/26335
Bibliographic Citation
IOC/WESTPAC, pp.210, 2014
Publisher
베트남
Type
Conference
Language
English
Publisher
베트남
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