Thienopyridinone 유도체의 효율적인 합성

Title
Thienopyridinone 유도체의 효율적인 합성
Alternative Title
Efficient Synthesis of Thienopyridinone Derivatives
Author(s)
박솔; 설재희; 이연주; 이지훈; 이희승; 신희재; 이종석
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Ji Hoon(이지훈)Lee, Hyi Seung(이희승)Shin, Hee Jae(신희재)Lee, Jong Seok(이종석)
Alternative Author(s)
박솔; 설재희; 이연주; 이지훈; 이희승; 신희재; 이종석
Publication Year
2015-10-23
Abstract
Sulphur- and nitrogen-containing heterocycles are known to have a broad spectrum of biological and pharmacological activities. For these reasons, thieno-pyridinone has been recognized as a important chemical scaffold.In our research program, we found an efficient process for the formation of thienopyridinone and derivaties. This method features using BOP and DIEA as amide coupling reagent. Then it was used for the O-methylation and O-arylation reaction. The synthesis of thienopyridinone is described in this presentation. (1) Amide coupling reaction and cyclization reaction of thiophene. (2) Aromatization reaction of thienopyridinone. (3) O-methylation and O-arylation reaction of thienopyridinone.am, we found an efficient process for the formation of thienopyridinone and derivaties. This method features using BOP and DIEA as amide coupling reagent. Then it was used for the O-methylation and O-arylation reaction. The synthesis of thienopyridinone is described in this presentation. (1) Amide coupling reaction and cyclization reaction of thiophene. (2) Aromatization reaction of thienopyridinone. (3) O-methylation and O-arylation reaction of thienopyridinone.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/25224
Bibliographic Citation
2015 추계국제학술대회, pp.83, 2015
Publisher
대한약학회
Type
Conference
Language
English
Publisher
대한약학회
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