Bile Acids from a Marine Sponge-Associated Fungus Penicillium sp. 108YD020

Title
Bile Acids from a Marine Sponge-Associated Fungus Penicillium sp. 108YD020
Author(s)
필감방; 이화선; 최병규; 이희승; 이종석; 이연주; 이지훈; 신희재
KIOST Author(s)
Lee, Hwa Sun(이화선)Choi, Byeoung Kyu(최병규)Lee, Hyi Seung(이희승)Lee, Jong Seok(이종석)Lee, Yeon Ju(이연주)Lee, Jihoon(이지훈)
Publication Year
2016-04-22
Abstract
Bile acids are principal ingredients of bile synthesized in the liver of vertebrates such as mammals and fish, and secreted into the duodenum to play an important role in lipid metabolism. They include cholic acid (CA), chenocholic acid (CCA), deoxycholic acid (DCA) and their conjugates with glycine and taurine, which contribute to bile formation. A variety of bile acids have a steroid skeleton and carboxylic side chain. In addition, bile acids have been reported that they are different in the number and substituted position of the hydroxyl group and side chain length. The strain 108YD020 was isolated as various bile acid-producing microorganism from a marine sponge collected at Wangdolcho, East sea, Korea and identified as Penicillium sp. We obtained six bile acid derivatives and their structures were determined by the analysis of 1D, 2D NMR and LC-MS data, along with chemical methods and literature data analysis. This is the first report on the bile acids from marine fungi.A), deoxycholic acid (DCA) and their conjugates with glycine and taurine, which contribute to bile formation. A variety of bile acids have a steroid skeleton and carboxylic side chain. In addition, bile acids have been reported that they are different in the number and substituted position of the hydroxyl group and side chain length. The strain 108YD020 was isolated as various bile acid-producing microorganism from a marine sponge collected at Wangdolcho, East sea, Korea and identified as Penicillium sp. We obtained six bile acid derivatives and their structures were determined by the analysis of 1D, 2D NMR and LC-MS data, along with chemical methods and literature data analysis. This is the first report on the bile acids from marine fungi.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/24861
Bibliographic Citation
한국생물공학회, pp.127, 2016
Publisher
한국생물공학회
Type
Conference
Language
English
Publisher
한국생물공학회
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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