베이직 섬유아 세포 성장인자의 안정화 요인 검색

Title
베이직 섬유아 세포 성장인자의 안정화 요인 검색
Alternative Title
Search for stabilizing factors of Basic Fibroblast Growth Factor
Author(s)
안영준; 임형순
KIOST Author(s)
Yim, Hyung Soon(임형순)
Publication Year
2018-03-28
Abstract
Fibroblast growth factor1 (FGF1), the paracrine that activates signaling tyrosine kinase FGF receptors (FGFRs) with heparin or heparan sulfate (HS), is generally known to play important roles in embryonic development, wound healing, neurogenesis, angiogenesis, nutrient stress, glycaemic control and insulin sensitivity and therefore regarded as one of potential therapeutic proteins. However, FGFs must overcome low stability to be used as a medication. Our study based on structures model of paracrine FGFs (FGF1/FGF2) that tightly binds to heparin and BME showed that sulfur compound or reducing agents improved stability although requiring relatively high concentration to show the effect. The results will help studying and enhancing the stability of FGF1.nesis, angiogenesis, nutrient stress, glycaemic control and insulin sensitivity and therefore regarded as one of potential therapeutic proteins. However, FGFs must overcome low stability to be used as a medication. Our study based on structures model of paracrine FGFs (FGF1/FGF2) that tightly binds to heparin and BME showed that sulfur compound or reducing agents improved stability although requiring relatively high concentration to show the effect. The results will help studying and enhancing the stability of FGF1.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/23453
Bibliographic Citation
Fibroblast Growth Factors in Development and Disease, 2018
Publisher
Gordon
Type
Conference
Language
English
Publisher
Gordon
Related Researcher
Research Interests

marine genomics,biochemistry,molecular cell biology,해양 유전체,생화학,세포분자 생물학

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