베이직 섬유아 세포 성장인자의 안정화 요인 검색

DC Field Value Language
dc.contributor.author 안영준 -
dc.contributor.author 임형순 -
dc.date.accessioned 2020-07-15T12:52:51Z -
dc.date.available 2020-07-15T12:52:51Z -
dc.date.created 2020-02-11 -
dc.date.issued 2018-03-28 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/23453 -
dc.description.abstract Fibroblast growth factor1 (FGF1), the paracrine that activates signaling tyrosine kinase FGF receptors (FGFRs) with heparin or heparan sulfate (HS), is generally known to play important roles in embryonic development, wound healing, neurogenesis, angiogenesis, nutrient stress, glycaemic control and insulin sensitivity and therefore regarded as one of potential therapeutic proteins. However, FGFs must overcome low stability to be used as a medication. Our study based on structures model of paracrine FGFs (FGF1/FGF2) that tightly binds to heparin and BME showed that sulfur compound or reducing agents improved stability although requiring relatively high concentration to show the effect. The results will help studying and enhancing the stability of FGF1.nesis, angiogenesis, nutrient stress, glycaemic control and insulin sensitivity and therefore regarded as one of potential therapeutic proteins. However, FGFs must overcome low stability to be used as a medication. Our study based on structures model of paracrine FGFs (FGF1/FGF2) that tightly binds to heparin and BME showed that sulfur compound or reducing agents improved stability although requiring relatively high concentration to show the effect. The results will help studying and enhancing the stability of FGF1. -
dc.description.uri 1 -
dc.language English -
dc.publisher Gordon -
dc.relation.isPartOf Fibroblast Growth Factors in Development and Disease -
dc.title 베이직 섬유아 세포 성장인자의 안정화 요인 검색 -
dc.title.alternative Search for stabilizing factors of Basic Fibroblast Growth Factor -
dc.type Conference -
dc.citation.conferencePlace US -
dc.citation.title Fibroblast Growth Factors in Development and Disease -
dc.contributor.alternativeName 안영준 -
dc.contributor.alternativeName 임형순 -
dc.identifier.bibliographicCitation Fibroblast Growth Factors in Development and Disease -
dc.description.journalClass 1 -
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Marine Resources Research Division > Marine Biotechnology Research Center > 2. Conference Papers
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