Soft Coral Dendronephthya puetteri Extract Ameliorates Inflammations by Suppressing Inflammatory Mediators and Oxidative Stress in LPS-Stimulated Zebrafish SCIE SCOPUS

Cited 4 time in WEB OF SCIENCE Cited 3 time in Scopus
Title
Soft Coral Dendronephthya puetteri Extract Ameliorates Inflammations by Suppressing Inflammatory Mediators and Oxidative Stress in LPS-Stimulated Zebrafish
Author(s)
Kim, Eun-A; Ding, Yuling; Yang, Hye-Won; Heo, Soo-Jin; Lee, Seung-Hong
KIOST Author(s)
Kim, Eun A(김은아)Heo, Soo Jin(허수진)
Publication Year
2018-09
Abstract
Marine-derived extract and/or bioactive compounds have attracted increasing demand due to their unique and potential uses as cures for various inflammation-based diseases. Several studies revealed anti-inflammatory candidates found in soft corals. However, the effects of soft corals on inflammation in an in vivo model remain to be determined. Therefore, the extract of soft coral Dendronephthya puetteri (DPE) was investigated for an in vivo anti-inflammatory effect in a lipopolysaccharide (LPS)-stimulated zebrafish model to determine its potential use as a natural anti-inflammatory agent. We also investigated whether DPE has toxic effects in a zebrafish model. No significant changes were observed in terms of survival, heart beat rate, or developmental abnormalities in the zebrafish embryos exposed to a concentration below 100 mu g/mL of DPE. Treating the zebrafish model with LPS-treatment significantly increased the ROS, NO generation, and cell death. However, DPE inhibited this LPS-stimulated ROS, NO generation, and cell death in a dose-dependent manner. In addition, DPE significantly reduced the mRNA expression of both iNOS and COX-2 and markedly suppressed the expression levels of the proinflammatory cytokines, TNF-alpha and IL-6, in an LPS-stimulated zebrafish model. These findings demonstrate that DPE has profound anti-inflammatory effect in vivo, suggesting that DPE might be a strong natural anti-inflammatory agent.
ISSN
1422-0067
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/850
DOI
10.3390/ijms19092695
Bibliographic Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.19, no.9, 2018
Publisher
MDPI
Subject
ANTIINFLAMMATORY ACTIVITY; ECKLONIA-CAVA; IN-VIVO; STEROIDS; MODEL; EXPRESSION; GENERATION; GIGANTEA; LARVAE
Keywords
soft coral; Dendronephthya puetteri; anti-inflammatory effect; zebrafish model
Type
Article
Language
English
Document Type
Article
Publisher
MDPI
Related Researcher
Research Interests

Marine Biotechnology,Marine Natural Products,Bioactivities,해양생물공학,해양천연물학,생리활성

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