Soft Coral Dendronephthya puetteri Extract Ameliorates Inflammations by Suppressing Inflammatory Mediators and Oxidative Stress in LPS-Stimulated Zebrafish SCIE SCOPUS

DC Field Value Language
dc.contributor.author Kim, Eun-A -
dc.contributor.author Ding, Yuling -
dc.contributor.author Yang, Hye-Won -
dc.contributor.author Heo, Soo-Jin -
dc.contributor.author Lee, Seung-Hong -
dc.date.accessioned 2020-04-16T08:40:19Z -
dc.date.available 2020-04-16T08:40:19Z -
dc.date.created 2020-01-28 -
dc.date.issued 2018-09 -
dc.identifier.issn 1422-0067 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/850 -
dc.description.abstract Marine-derived extract and/or bioactive compounds have attracted increasing demand due to their unique and potential uses as cures for various inflammation-based diseases. Several studies revealed anti-inflammatory candidates found in soft corals. However, the effects of soft corals on inflammation in an in vivo model remain to be determined. Therefore, the extract of soft coral Dendronephthya puetteri (DPE) was investigated for an in vivo anti-inflammatory effect in a lipopolysaccharide (LPS)-stimulated zebrafish model to determine its potential use as a natural anti-inflammatory agent. We also investigated whether DPE has toxic effects in a zebrafish model. No significant changes were observed in terms of survival, heart beat rate, or developmental abnormalities in the zebrafish embryos exposed to a concentration below 100 mu g/mL of DPE. Treating the zebrafish model with LPS-treatment significantly increased the ROS, NO generation, and cell death. However, DPE inhibited this LPS-stimulated ROS, NO generation, and cell death in a dose-dependent manner. In addition, DPE significantly reduced the mRNA expression of both iNOS and COX-2 and markedly suppressed the expression levels of the proinflammatory cytokines, TNF-alpha and IL-6, in an LPS-stimulated zebrafish model. These findings demonstrate that DPE has profound anti-inflammatory effect in vivo, suggesting that DPE might be a strong natural anti-inflammatory agent. -
dc.description.uri 1 -
dc.language English -
dc.publisher MDPI -
dc.subject ANTIINFLAMMATORY ACTIVITY -
dc.subject ECKLONIA-CAVA -
dc.subject IN-VIVO -
dc.subject STEROIDS -
dc.subject MODEL -
dc.subject EXPRESSION -
dc.subject GENERATION -
dc.subject GIGANTEA -
dc.subject LARVAE -
dc.title Soft Coral Dendronephthya puetteri Extract Ameliorates Inflammations by Suppressing Inflammatory Mediators and Oxidative Stress in LPS-Stimulated Zebrafish -
dc.type Article -
dc.citation.title INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES -
dc.citation.volume 19 -
dc.citation.number 9 -
dc.contributor.alternativeName 김은아 -
dc.contributor.alternativeName 허수진 -
dc.identifier.bibliographicCitation INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.19, no.9 -
dc.identifier.doi 10.3390/ijms19092695 -
dc.identifier.scopusid 2-s2.0-85053346719 -
dc.identifier.wosid 000449988100231 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus ANTIINFLAMMATORY ACTIVITY -
dc.subject.keywordPlus ECKLONIA-CAVA -
dc.subject.keywordPlus IN-VIVO -
dc.subject.keywordPlus STEROIDS -
dc.subject.keywordPlus MODEL -
dc.subject.keywordPlus EXPRESSION -
dc.subject.keywordPlus GENERATION -
dc.subject.keywordPlus GIGANTEA -
dc.subject.keywordPlus LARVAE -
dc.subject.keywordAuthor soft coral -
dc.subject.keywordAuthor Dendronephthya puetteri -
dc.subject.keywordAuthor anti-inflammatory effect -
dc.subject.keywordAuthor zebrafish model -
dc.relation.journalWebOfScienceCategory Biochemistry & Molecular Biology -
dc.relation.journalWebOfScienceCategory Chemistry, Multidisciplinary -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Biochemistry & Molecular Biology -
dc.relation.journalResearchArea Chemistry -
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Jeju Research Institute > Jeju Bio Research Center > 1. Journal Articles
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