Bromopyrrole Alkaloids from the Sponge Agelas kosrae
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Title
- Bromopyrrole Alkaloids from the Sponge Agelas kosrae
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Author(s)
- Kwon, Oh-Seok; Kim, Donghwa; Kim, Heegyu; Lee, Yeon-Ju; Lee, Hyi-Seung; Sim, Chung J.; Oh, Dong-Chan; Lee, Sang Kook; Oh, Ki-Bong; Shin, Jongheon
- KIOST Author(s)
- Lee, Yeon Ju(이연주); Lee, Hyi Seung(이희승)
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Alternative Author(s)
- 이연주; 이희승
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Publication Year
- 2018-12
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Abstract
- Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of -amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively.
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ISSN
- 1660-3397
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/794
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DOI
- 10.3390/md16120513
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Bibliographic Citation
- MARINE DRUGS, v.16, no.12, 2018
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Publisher
- MDPI
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Subject
- MARINE; METABOLITES; HANISHIN; SCEPTRIN; OROIDIN
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Keywords
- sceptrin; pyrrole-imidazole alkaloids; marine sponge; anti-angiogenesis; isocitrate lyase; bioactive marine natural products
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Type
- Article
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Language
- English
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Document Type
- Article
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