Bromopyrrole Alkaloids from the Sponge Agelas kosrae SCIE SCOPUS

Cited 8 time in WEB OF SCIENCE Cited 8 time in Scopus
Title
Bromopyrrole Alkaloids from the Sponge Agelas kosrae
Author(s)
Kwon, Oh-Seok; Kim, Donghwa; Kim, Heegyu; Lee, Yeon-Ju; Lee, Hyi-Seung; Sim, Chung J.; Oh, Dong-Chan; Lee, Sang Kook; Oh, Ki-Bong; Shin, Jongheon
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)
Alternative Author(s)
이연주; 이희승
Publication Year
2018-12
Abstract
Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of -amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively.
ISSN
1660-3397
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/794
DOI
10.3390/md16120513
Bibliographic Citation
MARINE DRUGS, v.16, no.12, 2018
Publisher
MDPI
Subject
MARINE; METABOLITES; HANISHIN; SCEPTRIN; OROIDIN
Keywords
sceptrin; pyrrole-imidazole alkaloids; marine sponge; anti-angiogenesis; isocitrate lyase; bioactive marine natural products
Type
Article
Language
English
Document Type
Article
Publisher
MDPI
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