Bromopyrrole Alkaloids from the Sponge Agelas kosrae SCIE SCOPUS

DC Field Value Language
dc.contributor.author Kwon, Oh-Seok -
dc.contributor.author Kim, Donghwa -
dc.contributor.author Kim, Heegyu -
dc.contributor.author Lee, Yeon-Ju -
dc.contributor.author Lee, Hyi-Seung -
dc.contributor.author Sim, Chung J. -
dc.contributor.author Oh, Dong-Chan -
dc.contributor.author Lee, Sang Kook -
dc.contributor.author Oh, Ki-Bong -
dc.contributor.author Shin, Jongheon -
dc.date.accessioned 2020-04-16T08:40:04Z -
dc.date.available 2020-04-16T08:40:04Z -
dc.date.created 2020-01-28 -
dc.date.issued 2018-12 -
dc.identifier.issn 1660-3397 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/794 -
dc.description.abstract Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of -amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively. -
dc.description.uri 1 -
dc.language English -
dc.publisher MDPI -
dc.subject MARINE -
dc.subject METABOLITES -
dc.subject HANISHIN -
dc.subject SCEPTRIN -
dc.subject OROIDIN -
dc.title Bromopyrrole Alkaloids from the Sponge Agelas kosrae -
dc.type Article -
dc.citation.title MARINE DRUGS -
dc.citation.volume 16 -
dc.citation.number 12 -
dc.contributor.alternativeName 이연주 -
dc.contributor.alternativeName 이희승 -
dc.identifier.bibliographicCitation MARINE DRUGS, v.16, no.12 -
dc.identifier.doi 10.3390/md16120513 -
dc.identifier.scopusid 2-s2.0-85058813532 -
dc.identifier.wosid 000454726400054 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus MARINE -
dc.subject.keywordPlus METABOLITES -
dc.subject.keywordPlus HANISHIN -
dc.subject.keywordPlus SCEPTRIN -
dc.subject.keywordPlus OROIDIN -
dc.subject.keywordAuthor sceptrin -
dc.subject.keywordAuthor pyrrole-imidazole alkaloids -
dc.subject.keywordAuthor marine sponge -
dc.subject.keywordAuthor anti-angiogenesis -
dc.subject.keywordAuthor isocitrate lyase -
dc.subject.keywordAuthor bioactive marine natural products -
dc.relation.journalWebOfScienceCategory Chemistry, Medicinal -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Pharmacology & Pharmacy -
Appears in Collections:
Marine Resources Research Division > Marine Biotechnology Research Center > 1. Journal Articles
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