Oxygen-mediated growth enhancement of an obligate anaerobic archaeon Thermococcus onnurineus NA1
SCIE
SCOPUS
KCI
Cited 2 time in
WEB OF SCIENCE
Cited 2 time in
Scopus
-
Title
- Oxygen-mediated growth enhancement of an obligate anaerobic archaeon Thermococcus onnurineus NA1
-
Author(s)
- Lee, Seong Hyuk; Youn, Hwan; Kang, Sung Gyun; Lee, Hyun Sook
- KIOST Author(s)
- Lee, Seong Hyuk(이성혁); Kang, Sung Gyun(강성균); Lee, Hyun Sook(이현숙)
-
Alternative Author(s)
- 이성혁; 강성균; 이현숙
-
Publication Year
- 2019-02
-
Abstract
- Thermococcus onnurineus NA1, an obligate anaerobic hyperthermophilic archaeon, showed variable oxygen (O-2) sensitivity depending on the types of substrate employed as an energy source. Unexpectedly, the culture with yeast extract as a sole energy source showed enhanced growth by 2-fold in the presence of O-2. Genome-wide transcriptome analysis revealed the upregulation of several antioxidant-related genes encoding thioredoxin peroxidase (TON_0862), rubrerythrin (TON_0864), rubrerythrin-related protein (TON_0873), NAD(P)H rubredoxin oxidoreductase (TON_0865), or thioredoxin reductase (TON_1603), which can couple the detoxification of reactive oxygen species with the regeneration of NAD(P)(+) from NAD(P)H. We present a plausible mechanism by which O-2 serves to maintain the intracellular redox balance. This study demonstrates an unusual strategy of an obligate anaerobe underlying O-2-mediated growth enhancement despite not having heme-based or cytochrome-type proteins.
-
ISSN
- 1225-8873
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/689
-
DOI
- 10.1007/s12275-019-8592-y
-
Bibliographic Citation
- JOURNAL OF MICROBIOLOGY, v.57, no.2, pp.138 - 142, 2019
-
Publisher
- MICROBIOLOGICAL SOCIETY KOREA
-
Subject
- NADH OXIDASE; HYPERTHERMOPHILIC ARCHAEON; DETOXIFICATION; PURIFICATION; SUPEROXIDE; PROTECTION; MICROBES
-
Keywords
- oxygen; obligate anaerobic archaeon; Thermococcus onnurineus NA1; transcriptome analysis; antioxidant enzymes
-
Type
- Article
-
Language
- English
-
Document Type
- Article
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.