Oxygen-mediated growth enhancement of an obligate anaerobic archaeon Thermococcus onnurineus NA1 SCIE SCOPUS KCI

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Title
Oxygen-mediated growth enhancement of an obligate anaerobic archaeon Thermococcus onnurineus NA1
Author(s)
Lee, Seong Hyuk; Youn, Hwan; Kang, Sung Gyun; Lee, Hyun Sook
KIOST Author(s)
Lee, Seong Hyuk(이성혁)Kang, Sung Gyun(강성균)Lee, Hyun Sook(이현숙)
Publication Year
2019-02
Abstract
Thermococcus onnurineus NA1, an obligate anaerobic hyperthermophilic archaeon, showed variable oxygen (O-2) sensitivity depending on the types of substrate employed as an energy source. Unexpectedly, the culture with yeast extract as a sole energy source showed enhanced growth by 2-fold in the presence of O-2. Genome-wide transcriptome analysis revealed the upregulation of several antioxidant-related genes encoding thioredoxin peroxidase (TON_0862), rubrerythrin (TON_0864), rubrerythrin-related protein (TON_0873), NAD(P)H rubredoxin oxidoreductase (TON_0865), or thioredoxin reductase (TON_1603), which can couple the detoxification of reactive oxygen species with the regeneration of NAD(P)(+) from NAD(P)H. We present a plausible mechanism by which O-2 serves to maintain the intracellular redox balance. This study demonstrates an unusual strategy of an obligate anaerobe underlying O-2-mediated growth enhancement despite not having heme-based or cytochrome-type proteins.
ISSN
1225-8873
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/689
DOI
10.1007/s12275-019-8592-y
Bibliographic Citation
JOURNAL OF MICROBIOLOGY, v.57, no.2, pp.138 - 142, 2019
Publisher
MICROBIOLOGICAL SOCIETY KOREA
Subject
NADH OXIDASE; HYPERTHERMOPHILIC ARCHAEON; DETOXIFICATION; PURIFICATION; SUPEROXIDE; PROTECTION; MICROBES
Keywords
oxygen; obligate anaerobic archaeon; Thermococcus onnurineus NA1; transcriptome analysis; antioxidant enzymes
Type
Article
Language
English
Document Type
Article
Publisher
MICROBIOLOGICAL SOCIETY KOREA
Related Researcher
Research Interests

Marine extremophile,해양극한미생물

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