Anti-angiogenic activity of acalycixenolide E, a novel marine natural product from Acalycigorgia inermis SCIE SCOPUS KCI

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Title
Anti-angiogenic activity of acalycixenolide E, a novel marine natural product from Acalycigorgia inermis
Author(s)
Kwon, HJ; Kim, JH; Jung, HJ; Kwon, YG; Kim, MY; Rho, JR; Shin, J
Alternative Author(s)
노정래; 신종헌
Publication Year
2001-08
Abstract
Angiogenesis is known as a crucial process in the growth and spreading of tumor cells. Accordingly, the effective inhibition of this process would appear to be a promising way to cure angiogenesis-related diseases, including cancer. This study demonstrates that acalycixenolide E (AX-E) from the marine organism Acalycigorgia inermis exhibits a potent antiangiogenic activity both in vitro and in vivo. AX-F inhibits the bFGF-induced proliferation of HUVECs in a dose dependent manner, along with the bFGF-induced migration, invasion, and tube formation of HUVECs. Moreover, AX-E potently inhibits the in vivo neovascularization of the chorioallantoic membranes (CAMS) of growing chick embryos. Interestingly, AX-E suppresses the expression of metalloproteases 2 and 9, yet shows no effect on their activities. The novel chemical structure and potent anti-angiogenic activity of AX-E will be of great value in elucidating the molecular mechanism of angiogenesis as well as in the development of a novel antiangiogenic drug.
ISSN
1017-7825
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/5872
Bibliographic Citation
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.11, no.4, pp.656 - 662, 2001
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
Keywords
anti-angiogenic agents; acalycixenolide E; Acalycigorgia inermis
Type
Article
Language
English
Document Type
Article
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
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