Anti-angiogenic activity of acalycixenolide E, a novel marine natural product from Acalycigorgia inermis SCIE SCOPUS KCI
DC Field | Value | Language |
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dc.contributor.author | Kwon, HJ | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Jung, HJ | - |
dc.contributor.author | Kwon, YG | - |
dc.contributor.author | Kim, MY | - |
dc.contributor.author | Rho, JR | - |
dc.contributor.author | Shin, J | - |
dc.date.accessioned | 2020-04-21T07:55:03Z | - |
dc.date.available | 2020-04-21T07:55:03Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2001-08 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/5872 | - |
dc.description.abstract | Angiogenesis is known as a crucial process in the growth and spreading of tumor cells. Accordingly, the effective inhibition of this process would appear to be a promising way to cure angiogenesis-related diseases, including cancer. This study demonstrates that acalycixenolide E (AX-E) from the marine organism Acalycigorgia inermis exhibits a potent antiangiogenic activity both in vitro and in vivo. AX-F inhibits the bFGF-induced proliferation of HUVECs in a dose dependent manner, along with the bFGF-induced migration, invasion, and tube formation of HUVECs. Moreover, AX-E potently inhibits the in vivo neovascularization of the chorioallantoic membranes (CAMS) of growing chick embryos. Interestingly, AX-E suppresses the expression of metalloproteases 2 and 9, yet shows no effect on their activities. The novel chemical structure and potent anti-angiogenic activity of AX-E will be of great value in elucidating the molecular mechanism of angiogenesis as well as in the development of a novel antiangiogenic drug. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY | - |
dc.title | Anti-angiogenic activity of acalycixenolide E, a novel marine natural product from Acalycigorgia inermis | - |
dc.type | Article | - |
dc.citation.endPage | 662 | - |
dc.citation.startPage | 656 | - |
dc.citation.title | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.citation.volume | 11 | - |
dc.citation.number | 4 | - |
dc.contributor.alternativeName | 노정래 | - |
dc.contributor.alternativeName | 신종헌 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.11, no.4, pp.656 - 662 | - |
dc.identifier.wosid | 000170841600017 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | 2 EPOXIDE GROUPS | - |
dc.subject.keywordPlus | MICROBIAL METABOLITE | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ENDOSTATIN | - |
dc.subject.keywordPlus | DEPUDECIN | - |
dc.subject.keywordPlus | ANGIOSTATIN | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordAuthor | anti-angiogenic agents | - |
dc.subject.keywordAuthor | acalycixenolide E | - |
dc.subject.keywordAuthor | Acalycigorgia inermis | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |