Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation SCIE SCOPUS

Cited 62 time in WEB OF SCIENCE Cited 48 time in Scopus
Title
Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation
Author(s)
Shim, JS; Kim, DH; Jung, HJ; Kim, JH; Lim, D; Lee, SK; Kim, KW; Ahn, JW; Yoo, JS; Rho, JR; Shin, J; Kwon, HJ
Publication Year
2002-09
Abstract
Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study. a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC50 = 520 nM) without cytotoxicity. In vivo and in Nitro angiogenesis experiments showed HC Lis a new candidate for anti-angiogenic agent. (C) 2002 Published by Elsevier Science Ltd.
ISSN
0968-0896
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/5670
DOI
10.1016/S0968-0896(02)00129-3
Bibliographic Citation
BIOORGANIC & MEDICINAL CHEMISTRY, v.10, no.9, pp.2987 - 2992, 2002
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
COLON CARCINOGENESIS; DIETARY CURCUMIN; TUMOR PROMOTION; ANGIOGENESIS; ANALOGS; TETRAHYDROCURCUMIN; MECHANISMS; GROWTH
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
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