Phenazine Derivatives with Anti-Inflammatory Activity from the Deep-Sea Sediment-Derived Yeast-Like Fungus Cystobasidium laryngis IV17-028 SCIE SCOPUS
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- Title
- Phenazine Derivatives with Anti-Inflammatory Activity from the Deep-Sea Sediment-Derived Yeast-Like Fungus Cystobasidium laryngis IV17-028
- KIOST Author(s)
- Lee, Hwa Sun(이화선); Lee, Hyi Seung(이희승); Lee, Yeon Ju(이연주); Lee, Ji Hoon(이지훈); Shin, Hee Jae(신희재)
- Alternative Author(s)
- 이화선; 최병규; 이희승; 이연주; 이지훈; 신희재
- Publication Year
- 2019-08
- Abstract
- Three new phenazine derivatives (1-3), along with known compounds (4-7) of saphenic acid derivatives, were isolated from a deep-sea sediment-derived yeast-like fungus Cystobasidium larynigs collected from the Indian Ocean. The structures of the new compounds (1-3) were determined by analysis of spectroscopic data, semi-synthesis and comparison of optical rotation values. All the isolated compounds (1-7), except for 2, showed nitric oxide (NO) production inhibitory effect against lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells without cytotoxicity at concentrations up to 30 mu g/mL. This is the first report on the yeast-like fungus Cystobasidium laryngis producing phenazines and anti-inflammatory activity of 1-7 including saphenic acid (4).
- ISSN
- 1660-3397
- Bibliographic Citation
- MARINE DRUGS, v.17, no.8, 2019
- Publisher
- MDPI
- Keywords
- deep-sea sediment; marine yeast-like fungi; Cystobasidium laryngis; phenazine derivatives; saphenic acid; anti-inflammatory activity
- Type
- Article
- Language
- English
- Document Type
- Article
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- There are no files associated with this item.
