Phenazine Derivatives with Anti-Inflammatory Activity from the Deep-Sea Sediment-Derived Yeast-Like Fungus Cystobasidium laryngis IV17-028 SCIE SCOPUS

Cited 4 time in WEB OF SCIENCE Cited 2 time in Scopus
Title
Phenazine Derivatives with Anti-Inflammatory Activity from the Deep-Sea Sediment-Derived Yeast-Like Fungus Cystobasidium laryngis IV17-028
Author(s)
Lee, Hwa-Sun; Kang, Jong Soon; Choi, Byeoung-Kyu; Lee, Hyi-Seung; Lee, Yeon-Ju; Lee, Jihoon; Shin, Hee Jae
KIOST Author(s)
Lee, Hwa Sun(이화선)Choi, Byeoung Kyu(최병규)Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)Lee, Ji Hoon(이지훈)
Publication Year
2019-08
Abstract
Three new phenazine derivatives (1-3), along with known compounds (4-7) of saphenic acid derivatives, were isolated from a deep-sea sediment-derived yeast-like fungus Cystobasidium larynigs collected from the Indian Ocean. The structures of the new compounds (1-3) were determined by analysis of spectroscopic data, semi-synthesis and comparison of optical rotation values. All the isolated compounds (1-7), except for 2, showed nitric oxide (NO) production inhibitory effect against lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells without cytotoxicity at concentrations up to 30 mu g/mL. This is the first report on the yeast-like fungus Cystobasidium laryngis producing phenazines and anti-inflammatory activity of 1-7 including saphenic acid (4).
ISSN
1660-3397
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/555
DOI
10.3390/md17080482
Bibliographic Citation
MARINE DRUGS, v.17, no.8, 2019
Publisher
MDPI
Keywords
deep-sea sediment; marine yeast-like fungi; Cystobasidium laryngis; phenazine derivatives; saphenic acid; anti-inflammatory activity
Type
Article
Language
English
Document Type
Article
Publisher
MDPI
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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