Antiviral effects of sulfated exopolysaccharide from the marine microalga Gyrodinium impudicum strain KG03 SCIE SCOPUS

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Title
Antiviral effects of sulfated exopolysaccharide from the marine microalga Gyrodinium impudicum strain KG03
Author(s)
Yim, JH; Kim, SJ; Ahn, SH; Lee, CK; Rhie, KT; Lee, HK
Publication Year
2004-01
Abstract
The sulfated exopolysaccharide p-KG03, which is produced by the marine microalga Gyrodinium impudicum strain KG03, exhibited impressive antiviral activity in vitro (EC50 = 26.9 mug/ml) against the encephalomyocarditis virus (EMCV). Depending on the p-KG03 concentration, the development of cytopathic effects in EMCV-infected HeLa cells was either inhibited completely or slowed. Moreover, p-KG03 did not show any cytotoxic effects on HeLa cells, even at concentrations up to 1000 mug/ml. The polysaccharide was purified by repeated precipitation in ethanol, followed by gel filtration. The p-KG03 polysaccharide had a molecular weight of 1.87 X 10(7), and was characterized as a homopolysaccharide of galactose with uronic acid (2.96% wt/wt) and sulfate groups (10.32% wt/wt). The biological activities of p-KG03 suggest that sulfated metabolites from marine organisms are a rich source of antiviral agents. This is the first reported marine source of antiviral sulfated polysaccharides against EMCV. The p-KG03 polysaccharide may be useful in the development of marine bioactive exopolysaccharide for biotechnological and pharmaceutical products.
ISSN
1436-2228
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/5311
DOI
10.1007/s10126-003-0002-z
Bibliographic Citation
MARINE BIOTECHNOLOGY, v.6, no.1, pp.17 - 25, 2004
Publisher
SPRINGER
Subject
HUMAN-IMMUNODEFICIENCY-VIRUS; BLUE-GREEN-ALGAE; ENVELOPED VIRUSES; COLORIMETRIC ASSAY; POLYSACCHARIDES; HIV; INHIBITORS; EXTRACTS
Keywords
marine microalga; Gyrodinium impudicum; sulfated exopolysaccharide; antiviral activity; encephalomyocarditis virus
Type
Article
Language
English
Document Type
Article
Publisher
SPRINGER
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