Antiviral effects of sulfated exopolysaccharide from the marine microalga Gyrodinium impudicum strain KG03 SCIE SCOPUS
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yim, JH | - |
dc.contributor.author | Kim, SJ | - |
dc.contributor.author | Ahn, SH | - |
dc.contributor.author | Lee, CK | - |
dc.contributor.author | Rhie, KT | - |
dc.contributor.author | Lee, HK | - |
dc.date.accessioned | 2020-04-20T15:25:37Z | - |
dc.date.available | 2020-04-20T15:25:37Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2004-01 | - |
dc.identifier.issn | 1436-2228 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/5311 | - |
dc.description.abstract | The sulfated exopolysaccharide p-KG03, which is produced by the marine microalga Gyrodinium impudicum strain KG03, exhibited impressive antiviral activity in vitro (EC50 = 26.9 mug/ml) against the encephalomyocarditis virus (EMCV). Depending on the p-KG03 concentration, the development of cytopathic effects in EMCV-infected HeLa cells was either inhibited completely or slowed. Moreover, p-KG03 did not show any cytotoxic effects on HeLa cells, even at concentrations up to 1000 mug/ml. The polysaccharide was purified by repeated precipitation in ethanol, followed by gel filtration. The p-KG03 polysaccharide had a molecular weight of 1.87 X 10(7), and was characterized as a homopolysaccharide of galactose with uronic acid (2.96% wt/wt) and sulfate groups (10.32% wt/wt). The biological activities of p-KG03 suggest that sulfated metabolites from marine organisms are a rich source of antiviral agents. This is the first reported marine source of antiviral sulfated polysaccharides against EMCV. The p-KG03 polysaccharide may be useful in the development of marine bioactive exopolysaccharide for biotechnological and pharmaceutical products. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | SPRINGER | - |
dc.subject | HUMAN-IMMUNODEFICIENCY-VIRUS | - |
dc.subject | BLUE-GREEN-ALGAE | - |
dc.subject | ENVELOPED VIRUSES | - |
dc.subject | COLORIMETRIC ASSAY | - |
dc.subject | POLYSACCHARIDES | - |
dc.subject | HIV | - |
dc.subject | INHIBITORS | - |
dc.subject | EXTRACTS | - |
dc.title | Antiviral effects of sulfated exopolysaccharide from the marine microalga Gyrodinium impudicum strain KG03 | - |
dc.type | Article | - |
dc.citation.endPage | 25 | - |
dc.citation.startPage | 17 | - |
dc.citation.title | MARINE BIOTECHNOLOGY | - |
dc.citation.volume | 6 | - |
dc.citation.number | 1 | - |
dc.contributor.alternativeName | 임정한 | - |
dc.contributor.alternativeName | 김성진 | - |
dc.contributor.alternativeName | 이홍금 | - |
dc.identifier.bibliographicCitation | MARINE BIOTECHNOLOGY, v.6, no.1, pp.17 - 25 | - |
dc.identifier.doi | 10.1007/s10126-003-0002-z | - |
dc.identifier.wosid | 000220334100003 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HUMAN-IMMUNODEFICIENCY-VIRUS | - |
dc.subject.keywordPlus | BLUE-GREEN-ALGAE | - |
dc.subject.keywordPlus | ENVELOPED VIRUSES | - |
dc.subject.keywordPlus | COLORIMETRIC ASSAY | - |
dc.subject.keywordPlus | POLYSACCHARIDES | - |
dc.subject.keywordPlus | HIV | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | EXTRACTS | - |
dc.subject.keywordAuthor | marine microalga | - |
dc.subject.keywordAuthor | Gyrodinium impudicum | - |
dc.subject.keywordAuthor | sulfated exopolysaccharide | - |
dc.subject.keywordAuthor | antiviral activity | - |
dc.subject.keywordAuthor | encephalomyocarditis virus | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Marine & Freshwater Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Marine & Freshwater Biology | - |