노닐페놀을 주사한 조피볼락의 간장 cytochrome P450과 EROD의 반응
KCI
OTHER
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Title
- 노닐페놀을 주사한 조피볼락의 간장 cytochrome P450과 EROD의 반응
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Alternative Title
- Responses of Cytochrome P450 and EROD Activity in Rockfish (Paralichthys olivaceus) Administered Intraperitoneal Injection of 4-nonylphenol
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Author(s)
- 전중균; 이지선; 손영창; 심원준; 정지현; 홍경표; 김병기; 한창희
- KIOST Author(s)
- Shim, Won Joon(심원준)
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Alternative Author(s)
- 심원준; 홍경표
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Publication Year
- 2004-03
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Abstract
- Nonyphenol (NP) used actively as non -ionic surfactant is classified as oneof most potent endocrine disrupting chemicals. Effects of NP on mixed functionoxygenase (MFO) system in rockfish ( Sebastes schlegeli ) were investigated for sevendays after intraperitoneal injection (10 and 25 mg kg-1). Hepatosomatic index (HSI) offishes exposed to NP of 25 mg kg-1 was significantly reduced compared to those incontrol group. NP exposure enhanced cytochrome P450 levels in the fish liver, while 7 -ethoxyresorufin -O-deethylase (EROD) activity was inhibited. NP exposure levels inthis study were much higher than those found in the coastal environment of Korea.Effects on HSI and liver MFO system, which is involved in steroid hormone metab-olism, imply that NP may influence on reproduction of fish by not only hormone recep-tor mediated response but also through effects on the MFO system.
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ISSN
- 1226-9999
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/5277
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Bibliographic Citation
- 환경생물, v.22, no.1, pp.171 - 176, 2004
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Publisher
- 한국환경생물학회
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Keywords
- 4-nonylphenol; rockfish; Sebastes schlegeli; cytochrome P450; EROD; hepatosomatic index
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Type
- Article
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