노닐페놀을 주사한 조피볼락의 간장 cytochrome P450과 EROD의 반응

Abstract

Nonyphenol (NP) used actively as non -ionic surfactant is classified as oneof most potent endocrine disrupting chemicals. Effects of NP on mixed functionoxygenase (MFO) system in rockfish ( Sebastes schlegeli ) were investigated for sevendays after intraperitoneal injection (10 and 25 mg kg-1). Hepatosomatic index (HSI) offishes exposed to NP of 25 mg kg-1 was significantly reduced compared to those incontrol group. NP exposure enhanced cytochrome P450 levels in the fish liver, while 7 -ethoxyresorufin -O-deethylase (EROD) activity was inhibited. NP exposure levels inthis study were much higher than those found in the coastal environment of Korea.Effects on HSI and liver MFO system, which is involved in steroid hormone metab-olism, imply that NP may influence on reproduction of fish by not only hormone recep-tor mediated response but also through effects on the MFO system.