노닐페놀을 주사한 조피볼락의 간장 cytochrome P450과 EROD의 반응 KCI OTHER

Title
노닐페놀을 주사한 조피볼락의 간장 cytochrome P450과 EROD의 반응
Alternative Title
Responses of Cytochrome P450 and EROD Activity in Rockfish (Paralichthys olivaceus) Administered Intraperitoneal Injection of 4-nonylphenol
Author(s)
전중균; 이지선; 손영창; 심원준; 정지현; 홍경표; 김병기; 한창희
KIOST Author(s)
Shim, Won Joon(심원준)
Publication Year
2004-03
Abstract
Nonyphenol (NP) used actively as non -ionic surfactant is classified as oneof most potent endocrine disrupting chemicals. Effects of NP on mixed functionoxygenase (MFO) system in rockfish ( Sebastes schlegeli ) were investigated for sevendays after intraperitoneal injection (10 and 25 mg kg-1). Hepatosomatic index (HSI) offishes exposed to NP of 25 mg kg-1 was significantly reduced compared to those incontrol group. NP exposure enhanced cytochrome P450 levels in the fish liver, while 7 -ethoxyresorufin -O-deethylase (EROD) activity was inhibited. NP exposure levels inthis study were much higher than those found in the coastal environment of Korea.Effects on HSI and liver MFO system, which is involved in steroid hormone metab-olism, imply that NP may influence on reproduction of fish by not only hormone recep-tor mediated response but also through effects on the MFO system.
ISSN
1226-9999
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/5277
Bibliographic Citation
환경생물, v.22, no.1, pp.171 - 176, 2004
Publisher
한국환경생물학회
Keywords
4-nonylphenol; rockfish; Sebastes schlegeli; cytochrome P450; EROD; hepatosomatic index
Type
Article
Publisher
한국환경생물학회
Related Researcher
Research Interests

Microplastic pollution,Persistent Organic Pollutants,Oil Pollution,미세플라스틱 오염,잔류성 유기오염물질,유류오염

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