Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp 04DH110 SCIE SCOPUS KCI
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- Title
- Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp 04DH110
- KIOST Author(s)
- Shin, Hee Jae(신희재); Lee, Hyi Seung(이희승)
- Alternative Author(s)
- 신희재; 이희승
- Publication Year
- 2007-08
- Abstract
- An antiproliferative agent, streptochlorin, was isolated from the fermentation broth of a marine actinomycete isolated from marine sediment. Phylogenetic analysis of the 16S rRNA gene sequence indicated that the strain belongs to the genus Streptomyces. Bioactivity guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and reversed-phase HPLC gave a pure compound, streptochlorin. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Streptochlorin exhibited significant antiproliferative activity against human cultured cell lines.
- ISSN
- 1017-7825
- Bibliographic Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.17, no.8, pp.1403 - 1406, 2007
- Publisher
- KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
- Subject
- BACTERIUM; DERIVATIVES
- Keywords
- Streptomyces sp 04DH110; antiproliferative agent; streptochlorin
- Type
- Article
- Language
- English
- Document Type
- Article
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- There are no files associated with this item.
