Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp 04DH110 SCIE SCOPUS KCI

Cited 42 time in WEB OF SCIENCE Cited 43 time in Scopus
Title
Isolation and structure determination of streptochlorin, an antiproliferative agent from a marine-derived Streptomyces sp 04DH110
Author(s)
Shin, Hee Jae; Jeong, Hyun Sun; Lee, Hyi-Seung; Park, Song-Kyu; Kim, Hwan Mook; Kwon, Ho Jeong
KIOST Author(s)
Shin, Hee Jae(신희재)Lee, Hyi Seung(이희승)
Publication Year
2007-08
Abstract
An antiproliferative agent, streptochlorin, was isolated from the fermentation broth of a marine actinomycete isolated from marine sediment. Phylogenetic analysis of the 16S rRNA gene sequence indicated that the strain belongs to the genus Streptomyces. Bioactivity guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and reversed-phase HPLC gave a pure compound, streptochlorin. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Streptochlorin exhibited significant antiproliferative activity against human cultured cell lines.
ISSN
1017-7825
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4669
Bibliographic Citation
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.17, no.8, pp.1403 - 1406, 2007
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
Subject
BACTERIUM; DERIVATIVES
Keywords
Streptomyces sp 04DH110; antiproliferative agent; streptochlorin
Type
Article
Language
English
Document Type
Article
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse