An anti-inflammatory compound isolated from marine-derived Bacillus subtilis 228DD-046
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Title
- An anti-inflammatory compound isolated from marine-derived Bacillus subtilis 228DD-046
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Author(s)
- Kim, Min Ji; Shin, Hee Jae
- KIOST Author(s)
- Kim, Min Ji(김민지); Shin, Hee Jae(신희재)
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Alternative Author(s)
- 김민지; 신희재
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Publication Year
- 2023-11-09
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Abstract
- In the course of our research on the bioactive secondary metabolites from marine microorganisms, we encountered a marine-derived bacterium Bacillus subtilis 228DD-046, which was isolated from a sediment sample collected off the coasts of Dokdo island, Republic of Korea. The strain 228DD-046 produced AI-77-f as a major secondary metabolite. The structure of AI-77-f was elucidated based on 1D NMR and mass spectrometric data analyses. The AI-77 series of compounds have been reported to exhibit a range of bioactivities, including antibacterial, cytotoxic, antiulcer against stress-induced ulcers, growth inhibition against barnyard millet, and anti-inflammatory effects. AI-77-f exhibited significant inhibitory activity toward NO production with an IC50 value of 27.8µM [1].
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/44785
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Bibliographic Citation
- 제19회 한국해양바이오학회 정기총회 및 학술발표회, pp.193, 2023
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Publisher
- 한국해양바이오학회
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Type
- Conference
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Language
- English
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