Polyoxygenated Diterpenes from the Sponge Phorbas sp.
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Title
- Polyoxygenated Diterpenes from the Sponge Phorbas sp.
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Author(s)
- Jang, Kyoung Hwa; Jeon, Ju-eun; Ryu, Sungkwang; Lee, Hyi-Seung; Oh, Ki-Bong; Shin, Jongheon
- KIOST Author(s)
- Lee, Hyi Seung(이희승)
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Alternative Author(s)
- 이희승
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Publication Year
- 2008-10
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Abstract
- Ten new polyoxygenated diterpenes (7-16) along with six known gagunin compounds (1-6) were isolated from the sponge Phorbas sp. collected in the Korean Sea. Oil the basis of a combination of NMR and mass spectroscopic analyses, the molecular structures of these diterpenes, designated as gagunins H-Q, were determined to be penta- or hexa-oxygenated diterpenes of the 10, 13-bis-epi-homoverrucosane class. A new diterpene acid (17) of a bisabolane-related skeletal class was also isolated and structurally defined by the spectroscopic analyses. These compounds exhibited moderate to significant cytoloxicity against the K-562 cell line as well as weak inhibitory activity against isocitrate lyase (ICL).
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ISSN
- 0163-3864
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/4445
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DOI
- 10.1021/np800293y
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Bibliographic Citation
- JOURNAL OF NATURAL PRODUCTS, v.71, no.10, pp.1701 - 1707, 2008
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Publisher
- AMER CHEMICAL SOC
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Subject
- AUSTRALIAN MARINE SPONGE; MYLIA-VERRUCOSA; A-D; ABSOLUTE-CONFIGURATION; LIVERWORT; PHORBOXAZOLES; AMARANTHUS; MACROLIDES
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Type
- Article
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Language
- English
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Document Type
- Article
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