Polyoxygenated Diterpenes from the Sponge Phorbas sp. SCIE SCOPUS

Cited 31 time in WEB OF SCIENCE Cited 29 time in Scopus
Title
Polyoxygenated Diterpenes from the Sponge Phorbas sp.
Author(s)
Jang, Kyoung Hwa; Jeon, Ju-eun; Ryu, Sungkwang; Lee, Hyi-Seung; Oh, Ki-Bong; Shin, Jongheon
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2008-10
Abstract
Ten new polyoxygenated diterpenes (7-16) along with six known gagunin compounds (1-6) were isolated from the sponge Phorbas sp. collected in the Korean Sea. Oil the basis of a combination of NMR and mass spectroscopic analyses, the molecular structures of these diterpenes, designated as gagunins H-Q, were determined to be penta- or hexa-oxygenated diterpenes of the 10, 13-bis-epi-homoverrucosane class. A new diterpene acid (17) of a bisabolane-related skeletal class was also isolated and structurally defined by the spectroscopic analyses. These compounds exhibited moderate to significant cytoloxicity against the K-562 cell line as well as weak inhibitory activity against isocitrate lyase (ICL).
ISSN
0163-3864
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4445
DOI
10.1021/np800293y
Bibliographic Citation
JOURNAL OF NATURAL PRODUCTS, v.71, no.10, pp.1701 - 1707, 2008
Publisher
AMER CHEMICAL SOC
Subject
AUSTRALIAN MARINE SPONGE; MYLIA-VERRUCOSA; A-D; ABSOLUTE-CONFIGURATION; LIVERWORT; PHORBOXAZOLES; AMARANTHUS; MACROLIDES
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
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