The Complete Genome Sequence of Thermococcus onnurineus NA1 Reveals a Mixed Heterotrophic and Carboxydotrophic Metabolism SCIE SCOPUS

Cited 108 time in WEB OF SCIENCE Cited 102 time in Scopus
Title
The Complete Genome Sequence of Thermococcus onnurineus NA1 Reveals a Mixed Heterotrophic and Carboxydotrophic Metabolism
Author(s)
Lee, Hyun Sook; Kang, Sung Gyun; Bae, Seung Seob; Lim, Jae Kyu; Cho, Yona; Kim, Yun Jae; Jeon, Jeong Ho; Cha, Sun-Shin; Kwon, Kae Kyoung; Kim, Hyung-Tae; Park, Cheol-Joo; Lee, Hee-Wook; Kim, Seung Il; Chun, Jongsik; Colwell, Rita R.; Kim, Sang-Jin; Lee, Jung-Hyun
KIOST Author(s)
Lee, Hyun Sook(이현숙)Kang, Sung Gyun(강성균)Kwon, Kae Kyoung(권개경)Lee, Jung Hyun(이정현)
Publication Year
2008-11
Abstract
Members of the genus Thermococcus, sulfur-reducing hyperthermophilic archaea, are ubiquitously present in various deep-sea hydrothermal vent systems and are considered to play a significant role in the microbial consortia. We present the complete genome sequence and feature analysis of Thermococcus onnurineus NA1 isolated from a deep-sea hydrothermal vent area, which reveal clues to its physiology. Based on results of genomic analysis, T. onnurineus NA1 possesses the metabolic pathways for organotrophic growth on peptides, amino acids, or sugars. More interesting was the discovery that the genome encoded unique proteins that are involved in carboxydotrophy to generate energy by oxidation of CO to CO(2), thereby providing a mechanistic basis for growth with CO as a substrate. This lithotrophic feature in combination with carbon fixation via RuBisCO (ribulose 1,5-bisphosphate carboxylase/oxygenase) introduces a new strategy with a complementing energy supply for T. onnurineus NA1 potentially allowing it to cope with nutrient stress in the surrounding of hydrothermal vents, providing the first genomic evidence for the carboxydotrophy in Thermococcus.
ISSN
0021-9193
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4434
DOI
10.1128/JB.00746-08
Bibliographic Citation
JOURNAL OF BACTERIOLOGY, v.190, no.22, pp.7491 - 7499, 2008
Publisher
AMER SOC MICROBIOLOGY
Subject
ARCHAEON PYROCOCCUS-FURIOSUS; SEA HYDROTHERMAL VENT; CARBON-MONOXIDE; RHODOSPIRILLUM-RUBRUM; PACIFIC-OCEAN; SP-NOV.; HYDROGENASE; CO; SULFUR; ENVIRONMENT
Type
Article
Language
English
Document Type
Article
Publisher
AMER SOC MICROBIOLOGY
Related Researcher
Research Interests

marine biotechnology,molecular microbiology,해양생명공학,분자미생물학

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