The Complete Genome Sequence of Thermococcus onnurineus NA1 Reveals a Mixed Heterotrophic and Carboxydotrophic Metabolism
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Title
- The Complete Genome Sequence of Thermococcus onnurineus NA1 Reveals a Mixed Heterotrophic and Carboxydotrophic Metabolism
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Author(s)
- Lee, Hyun Sook; Kang, Sung Gyun; Bae, Seung Seob; Lim, Jae Kyu; Cho, Yona; Kim, Yun Jae; Jeon, Jeong Ho; Cha, Sun-Shin; Kwon, Kae Kyoung; Kim, Hyung-Tae; Park, Cheol-Joo; Lee, Hee-Wook; Kim, Seung Il; Chun, Jongsik; Colwell, Rita R.; Kim, Sang-Jin; Lee, Jung-Hyun
- KIOST Author(s)
- Lee, Hyun Sook(이현숙); Kang, Sung Gyun(강성균); Lim, Jae Kyu(임재규); Kim, Yun Jae(김윤재); Kwon, Kae Kyoung(권개경); Lee, Jung Hyun(이정현)
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Alternative Author(s)
- 이현숙; 강성균; 배승섭; 임재규; 조요나; 김윤재; 전정호; 차선신; 권개경; 김상진; 이정현
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Publication Year
- 2008-11
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Abstract
- Members of the genus Thermococcus, sulfur-reducing hyperthermophilic archaea, are ubiquitously present in various deep-sea hydrothermal vent systems and are considered to play a significant role in the microbial consortia. We present the complete genome sequence and feature analysis of Thermococcus onnurineus NA1 isolated from a deep-sea hydrothermal vent area, which reveal clues to its physiology. Based on results of genomic analysis, T. onnurineus NA1 possesses the metabolic pathways for organotrophic growth on peptides, amino acids, or sugars. More interesting was the discovery that the genome encoded unique proteins that are involved in carboxydotrophy to generate energy by oxidation of CO to CO(2), thereby providing a mechanistic basis for growth with CO as a substrate. This lithotrophic feature in combination with carbon fixation via RuBisCO (ribulose 1,5-bisphosphate carboxylase/oxygenase) introduces a new strategy with a complementing energy supply for T. onnurineus NA1 potentially allowing it to cope with nutrient stress in the surrounding of hydrothermal vents, providing the first genomic evidence for the carboxydotrophy in Thermococcus.
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ISSN
- 0021-9193
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/4434
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DOI
- 10.1128/JB.00746-08
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Bibliographic Citation
- JOURNAL OF BACTERIOLOGY, v.190, no.22, pp.7491 - 7499, 2008
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Publisher
- AMER SOC MICROBIOLOGY
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Subject
- ARCHAEON PYROCOCCUS-FURIOSUS; SEA HYDROTHERMAL VENT; CARBON-MONOXIDE; RHODOSPIRILLUM-RUBRUM; PACIFIC-OCEAN; SP-NOV.; HYDROGENASE; CO; SULFUR; ENVIRONMENT
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Type
- Article
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Language
- English
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Document Type
- Article
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