Sesquiterpenes from Streptomyces qinglanensis and Their Cytotoxic Activity
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Title
- Sesquiterpenes from Streptomyces qinglanensis and Their Cytotoxic Activity
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Author(s)
- ANH, CAO VAN; Kang, Jong Soon; Yang, Jeong-Wook; Kwon, Joo-Hee; Heo, Chang Su; Lee, Hwa Sun; Park, Chan Hong; Shin, Hee Jae
- KIOST Author(s)
- Heo, Chang Su(허창수); Lee, Hwa Sun(이화선); Park, Chan Hong(박찬홍); Shin, Hee Jae(신희재)
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Alternative Author(s)
- Cao Van Anh; 허창수; 이화선; 박찬홍; 신희재
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Publication Year
- 2023-06
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Abstract
- Nine sesquiterpenes, including eight pentalenenes (1–8) and one bolinane derivative (9), were isolated from the culture broth of a marine-derived actinobacterium Streptomyces qinglanensis 213DD-006. Among them, 1, 4, 7, and 9 were new compounds. Their planar structures were determined by spectroscopic methods (HRMS, 1D, and 2D NMR), and the absolute configuration was established by biosynthesis consideration and electronic-circular-dichroism (ECD) calculations. All the isolated compounds were screened for their cytotoxicity against six solid and seven blood cancer cell lines. Compounds 4–6 and 8 showed a moderate activity against all of the tested solid cell lines, with GI50 values ranging from 1.97 to 3.46 µM.
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ISSN
- 1660-3397
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/44338
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DOI
- 10.3390/md21060361
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Bibliographic Citation
- Marine Drugs, v.21, no.6, 2023
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Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
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Keywords
- Streptomyces sp.; sesquiterpenes; pentalenene; bolinane; cytotoxicity
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Type
- Article
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Language
- English
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Document Type
- Article
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