Anti-inflammatory effect from viscera of Turbo cornutus extract against lipopolysaccharidestimulated inflammatory response through regulating MAPK and NF-kB signaling pathways in RAW 264.7 macrophages and zebrafish model
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Title
- Anti-inflammatory effect from viscera of Turbo cornutus extract against lipopolysaccharidestimulated inflammatory response through regulating MAPK and NF-kB signaling pathways in RAW 264.7 macrophages and zebrafish model
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Author(s)
- Kim, Eun A; Kang, Na Lae; Heo, Seong Yeong; Kim, Jun Seong; Park, Areumi; Lee, Yeon-Ji; Ahn, So Eon; Heo, Soo Jin
- KIOST Author(s)
- Kim, Eun A(김은아); Kang, Na Lae(강나래); Heo, Seong Yeong(허성영); Kim, Jun Seong(김준성); Park, Areumi(박아름이); Lee, Yeon-Ji(이연지); Ahn, So Eon(안소언); Heo, Soo Jin(허수진)
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Alternative Author(s)
- 김은아; 강나래; 허성영; 김준성; 박아름이; 이연지; 안소언; 허수진
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Publication Year
- 2022-10-19
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Abstract
- Turbo cornutus, the horned turban sea snail, is found along intertidal and basaltic shorelines and is an important fishery resource of Jeju Island. In this study, we investigated the anti-inflammatory effects of 70% ethanol extract from the viscera of T. cornutus (TVE) in in vitro LPS-stimulated RAW264.7 cells and in vivo zebrafish embryos. TVE reduced the production of LPS-stimulated NO and PGE2 without toxicity. Also, TVE downregulated the protein expression of LPS-induced iNOS and COX-2 and suppressed the production of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β. Furthermore, mechanistic studies indicated that TEV suppressed JNK phosphorylation and NF-kB activation. In zebrafish embryos, TEV did not show developmental toxicity according to the survival rate and cell death levels. In LPS-stimulated zebrafish embryos, TEV inhibited NO production and cell death levels. In conclusion, TVE has a potential anti-inflammatory property that can be exploited as a functional food ingredient.
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/43590
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Bibliographic Citation
- 2022 KFN International Symposium and Annual Meeting, 2022
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Publisher
- 한국식품영양과학회
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Type
- Conference
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