Anthracycline Antibiotics isolated from a Marine-Derived Actinomycete Streptomyces cinereoruber 112CH-337
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Title
- Anthracycline Antibiotics isolated from a Marine-Derived Actinomycete Streptomyces cinereoruber 112CH-337
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Author(s)
- Lee, Min Ah; Shin, Hee Jae; Lee, Hwa Sun; Kang, Jong Soon; Park, Sun Joo
- KIOST Author(s)
- Lee, Min Ah(이민아); Shin, Hee Jae(신희재); Lee, Hwa Sun(이화선)
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Alternative Author(s)
- 이민아; 신희재; 이화선
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Publication Year
- 2022-10-20
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Abstract
- The Streptomyces species are well known for their ability to produce secondary metabolites with various biological activities. This study focuses on the isolation of antimicrobial metabolites from a marine-derived strain of Streptomyces cinereoruber 112CH-337 isolated from a crown-of-thorns starfish, Acanthaster planci, collected from the Chuuk, Federated States of Micronesia. In the course of screening for new antimicrobial compounds, an extract of the strain 112CH-337 was found to exhibit potent antimicrobial activity. Bioassay-guided fractionation and purification of the culture extract of the strain 112CH-337 led to the isolation of two anthracycline derivatives known as α-citromycinone and β-rhodomycinone. These two anthracycline derivatives exhibited potent antimicrobial activities against both Gram-positive and negative bacteria. This is the first report on the isolation of α-citromycinone and β-rhodomycinone, anthracycline metabolites from a marine-derived S. cinereoruber 112CH-337.
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/43297
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Bibliographic Citation
- 2022 Fall International Convention of The Pharmaceutical Society of Korea (PSK), pp.742, 2022
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Publisher
- The Pharmaceutical Society of Korea (PSK)
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Type
- Conference
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Language
- English
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