Anthracycline Antibiotics isolated from a Marine-Derived Actinomycete Streptomyces cinereoruber 112CH-337
DC Field | Value | Language |
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dc.contributor.author | Lee, Min Ah | - |
dc.contributor.author | Shin, Hee Jae | - |
dc.contributor.author | Lee, Hwa Sun | - |
dc.contributor.author | Kang, Jong Soon | - |
dc.contributor.author | Park, Sun Joo | - |
dc.date.accessioned | 2022-10-25T01:50:16Z | - |
dc.date.available | 2022-10-25T01:50:16Z | - |
dc.date.created | 2022-10-25 | - |
dc.date.issued | 2022-10-20 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/43297 | - |
dc.description.abstract | The Streptomyces species are well known for their ability to produce secondary metabolites with various biological activities. This study focuses on the isolation of antimicrobial metabolites from a marine-derived strain of Streptomyces cinereoruber 112CH-337 isolated from a crown-of-thorns starfish, Acanthaster planci, collected from the Chuuk, Federated States of Micronesia. In the course of screening for new antimicrobial compounds, an extract of the strain 112CH-337 was found to exhibit potent antimicrobial activity. Bioassay-guided fractionation and purification of the culture extract of the strain 112CH-337 led to the isolation of two anthracycline derivatives known as α-citromycinone and β-rhodomycinone. These two anthracycline derivatives exhibited potent antimicrobial activities against both Gram-positive and negative bacteria. This is the first report on the isolation of α-citromycinone and β-rhodomycinone, anthracycline metabolites from a marine-derived S. cinereoruber 112CH-337. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | The Pharmaceutical Society of Korea (PSK) | - |
dc.title | Anthracycline Antibiotics isolated from a Marine-Derived Actinomycete Streptomyces cinereoruber 112CH-337 | - |
dc.type | Conference | - |
dc.citation.conferenceDate | 2022-10-19 | - |
dc.citation.conferencePlace | KO | - |
dc.citation.conferencePlace | Jeju Shinhwa World Landing Hall | - |
dc.citation.endPage | 742 | - |
dc.citation.startPage | 742 | - |
dc.citation.title | 2022 Fall International Convention of The Pharmaceutical Society of Korea (PSK) | - |
dc.contributor.alternativeName | 이민아 | - |
dc.contributor.alternativeName | 신희재 | - |
dc.contributor.alternativeName | 이화선 | - |
dc.identifier.bibliographicCitation | 2022 Fall International Convention of The Pharmaceutical Society of Korea (PSK), pp.742 | - |
dc.description.journalClass | 1 | - |