The Effects of Spirulina maxima Extract on Memory Improvement in Those with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial SCIE SCOPUS

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Title
The Effects of Spirulina maxima Extract on Memory Improvement in Those with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Author(s)
Choi, Yong Woon; Lee, Won Kyu; Kim, Tae Ho; Ryu, Yong Kyun; Park, Areumi; Lee, Yeon-Ji; Heo, Soo Jin; Oh, Chul Hong; Chung, Young-Chul; 강도형
KIOST Author(s)
Choi, Yong Woon(최운용)Lee, Won Kyu(이원규)Kim, Tae Ho(김태호)Ryu, Yong Kyun(유용균)Park, Areumi(박아름이)Lee, Yeon-Ji(이연지)Heo, Soo Jin(허수진)Oh, Chul Hong(오철홍)Kang, Do Hyung(강도형)
Alternative Author(s)
최운용; 이원규; 김태호; 유용균; 박아름이; 이연지; 허수진; 오철홍; 강도형
Publication Year
2022-09
Abstract
Spirulina maxima is a marine microalga that has been promoted worldwide as a super food. This study was conducted to evaluate its ability to improve memory in the older adults using Spirulina maxima 70% ethanol extract (SM70EE). This randomized, double-blind, placebo-controlled clinical trial comprised 80 volunteers recruited from Jeonbuk National University Hospital in Jeonju, Republic of Korea, who were randomly assigned to two groups. The participants received either 1 g/day of SM70EE or a placebo without otherwise changing their diet or physical activity. The participants were examined at baseline and after a 12-week interval to determine whether there were changes in their results for visual learning, visual working memory, and verbal learning tests from the Korean version of the Montreal Cognitive Assessment, brain-derived neurotrophic factor and beta-amyloid levels, and total antioxidant capacity. Compared to the placebo group, the treatment group showed a significant improvement in visual learning and visual working memory test results and enhanced vocabulary. SM70EE use was shown to improve memory, with no adverse effects. Its efficacy in alleviating Alzheimer’s disease symptoms was verified for the first time through this clinical trial. SM70EE could play a role in the management of patients with dementia. This trial is registered with registration number of clinical research information service (CRIS: KCT0006161).
ISSN
2072-6643
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/43216
DOI
10.3390/nu14183714
Bibliographic Citation
Nutrients, v.14, no.18, 2022
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
microalgae; cyanobacterium; Spirulina maxima; clinical trial; memory improvement; Alzheimer’s disease; functional food
Type
Article
Language
English
Document Type
Article
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
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