Phenotypic toxicity, oxidative response, and transcriptomic deregulation of the rotifer Brachionus plicatilis exposed to a toxic cocktail of tire-wear particle leachate SCIE SCOPUS

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Title
Phenotypic toxicity, oxidative response, and transcriptomic deregulation of the rotifer Brachionus plicatilis exposed to a toxic cocktail of tire-wear particle leachate
Author(s)
Shin, Heesang; Sukumaran, Vrinda; Yeo, In-Cheol; Shim, Kyu-Young; Lee, Seokhwan; Choi, Han-Kyu; Ha, Sung Yong; Kim, Moon Koo; Jung, Jee Hyun; Lee, Jae-Seong; Jeong, Chang-Bum
KIOST Author(s)
Ha, Sung Yong(하성용)Kim, Moon Koo(김문구)Jung, Jee Hyun(정지현)
Alternative Author(s)
하성용; 김문구; 정지현
Publication Year
2022-09
Abstract
Tire-wear particles (TWPs) are potential source of microplastic (MP) pollution in marine environments. Although the hazardous effects of MPs on marine biota have received considerable attention, the toxicity of TWPs and associated leachates remain poorly understood. Here, to assess the toxicity of TWP leachate and the underlying mechanisms of toxicity, the phenotypic and transcriptomic responses of the rotifer Brachionus plicatilis were assessed with chemistry analysis of a TWP leachate. Although acute toxicity was induced, and a variety of metals and polyaromatic hydrocarbons were detected in the leachate, levels were below the threshold for acute toxicity. The results of particle analysis suggest that the acute toxicity observed in our study is the result of a toxic cocktail of micro- and/or nano-sized TWPs and other additives in TWP leachate. The adverse effects of TWP leachate were associated with differential expression of genes related to cellular processes, stress response, and impaired metabolism, with further oxidative stress responses. Our results imply that TWPs pose a greater threat to marine
ISSN
0304-3894
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/43111
DOI
10.1016/j.jhazmat.2022.129417
Bibliographic Citation
Journal of Hazardous Materials, v.438, 2022
Publisher
Elsevier BV
Keywords
Leachate; Microplastic; Carbon black; Oxidative stress; Ecotoxicogenomics
Type
Article
Language
English
Document Type
Article
Publisher
Elsevier BV
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