Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent alpha-glucosidase and alpha-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic SCIE SCOPUS

Cited 167 time in WEB OF SCIENCE Cited 186 time in Scopus
Title
Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent alpha-glucosidase and alpha-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic
Author(s)
Heo, Soo Jin; Hwang, Ji-Young; Choi, Jung-In; Han, Ji-Sook; Kim, Hak-Ju; Jeon, You Jin
KIOST Author(s)
Heo, Soo Jin(허수진)
Publication Year
2009-08-01
Abstract
This study was designed to investigate whether diphlorethohydroxycarmalol (DPHC) may inhibit alpha-glucosidase and alpha-amylase activities, and alleviate postprandial hyperglycemia in streptozotocin-induced diabetic mice. DPHC isolated from Ishige okamurae, a brown algae, evidenced prominent inhibitory effect against alpha-glucosidase and alpha-amylase. The IC50 Values of DPHC against alpha-glucosidase and alpha-amylase were 0.16 and 0.53 mM, respectively, which evidenced the higher activities than that of acarbose. DPHC did not exert any cytotoxic effect in human umbilical vein endothelial cells (HUVECs) at various concentrations (from 0.49 to 3.91 mM). The increase of postprandial blood glucose levels were significantly suppressed. in the DPHC-administered group than those in the streptozotocin-induced diabetic or normal mice. Moreover, the area under curve (AUC) was significantly reduced via DPHC administration (2022 versus 2210 mmol-min/l) in the diabetic mice as well as it delays absorption of dietary carbohydrates. Therefore, these result indicated that DPHC might be a potent inhibitor for alpha-glucosidase and alpha-amylase. Crown Copyright 2009 Published by Elsevier B.V. All rights reserved.
ISSN
0014-2999
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4269
DOI
10.1016/j.ejphar.2009.05.017
Bibliographic Citation
EUROPEAN JOURNAL OF PHARMACOLOGY, v.615, no.1-3, pp.252 - 256, 2009
Publisher
ELSEVIER SCIENCE BV
Subject
ACARBOSE; MELLITUS; DISEASE; COMPLICATIONS; MICE
Keywords
Diphlorethohydroxycarmalol; alpha-glucosidase; alpha-amylase; Postprandial hyperglycemia; Diabetes
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER SCIENCE BV
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