Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent alpha-glucosidase and alpha-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic SCIE SCOPUS

DC Field Value Language
dc.contributor.author Heo, Soo Jin -
dc.contributor.author Hwang, Ji-Young -
dc.contributor.author Choi, Jung-In -
dc.contributor.author Han, Ji-Sook -
dc.contributor.author Kim, Hak-Ju -
dc.contributor.author Jeon, You Jin -
dc.date.accessioned 2020-04-20T09:40:23Z -
dc.date.available 2020-04-20T09:40:23Z -
dc.date.created 2020-01-28 -
dc.date.issued 2009-08-01 -
dc.identifier.issn 0014-2999 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/4269 -
dc.description.abstract This study was designed to investigate whether diphlorethohydroxycarmalol (DPHC) may inhibit alpha-glucosidase and alpha-amylase activities, and alleviate postprandial hyperglycemia in streptozotocin-induced diabetic mice. DPHC isolated from Ishige okamurae, a brown algae, evidenced prominent inhibitory effect against alpha-glucosidase and alpha-amylase. The IC50 Values of DPHC against alpha-glucosidase and alpha-amylase were 0.16 and 0.53 mM, respectively, which evidenced the higher activities than that of acarbose. DPHC did not exert any cytotoxic effect in human umbilical vein endothelial cells (HUVECs) at various concentrations (from 0.49 to 3.91 mM). The increase of postprandial blood glucose levels were significantly suppressed. in the DPHC-administered group than those in the streptozotocin-induced diabetic or normal mice. Moreover, the area under curve (AUC) was significantly reduced via DPHC administration (2022 versus 2210 mmol-min/l) in the diabetic mice as well as it delays absorption of dietary carbohydrates. Therefore, these result indicated that DPHC might be a potent inhibitor for alpha-glucosidase and alpha-amylase. Crown Copyright 2009 Published by Elsevier B.V. All rights reserved. -
dc.description.uri 1 -
dc.language English -
dc.publisher ELSEVIER SCIENCE BV -
dc.subject ACARBOSE -
dc.subject MELLITUS -
dc.subject DISEASE -
dc.subject COMPLICATIONS -
dc.subject MICE -
dc.title Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent alpha-glucosidase and alpha-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic -
dc.type Article -
dc.citation.endPage 256 -
dc.citation.startPage 252 -
dc.citation.title EUROPEAN JOURNAL OF PHARMACOLOGY -
dc.citation.volume 615 -
dc.citation.number 1-3 -
dc.identifier.bibliographicCitation EUROPEAN JOURNAL OF PHARMACOLOGY, v.615, no.1-3, pp.252 - 256 -
dc.identifier.doi 10.1016/j.ejphar.2009.05.017 -
dc.identifier.scopusid 2-s2.0-67449116102 -
dc.identifier.wosid 000268218100037 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus ACARBOSE -
dc.subject.keywordPlus MELLITUS -
dc.subject.keywordPlus DISEASE -
dc.subject.keywordPlus COMPLICATIONS -
dc.subject.keywordPlus MICE -
dc.subject.keywordAuthor Diphlorethohydroxycarmalol -
dc.subject.keywordAuthor alpha-glucosidase -
dc.subject.keywordAuthor alpha-amylase -
dc.subject.keywordAuthor Postprandial hyperglycemia -
dc.subject.keywordAuthor Diabetes -
dc.relation.journalWebOfScienceCategory Pharmacology & Pharmacy -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Pharmacology & Pharmacy -
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