Inhibitory Effects of Nitrogenous Metabolites from a Marine-Derived Streptomyces bacillaris on Isocitrate Lyase of Candida albicans
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Title
- Inhibitory Effects of Nitrogenous Metabolites from a Marine-Derived Streptomyces bacillaris on Isocitrate Lyase of Candida albicans
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Author(s)
- Chung, Beomkoo; Hwang, Ji-Yeon; Park, Sung Chul; Kwon, Oh-Seok; Cho, Eunji; Lee, Jayho; Lee, Hyi Seung; Oh, Dong-Chan; Shin, Jongheon; Oh, Ki-Bong
- KIOST Author(s)
- Lee, Hyi Seung(이희승)
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Alternative Author(s)
- 이희승
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Publication Year
- 2022-02
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Abstract
- Two nitrogenous metabolites, bacillimide (1) and bacillapyrrole (2), were isolated from the culture broth of the marine-derived actinomycete Streptomyces bacillaris. Based on the results of combined spectroscopic and chemical analyses, the structure of bacillimide (1) was determined to be a new cyclopenta[c]pyrrole-1,3-dione bearing a methylsulfide group, while the previously reported bacillapyrrole (2) was fully characterized for the first time as a pyrrole-carboxamide bearing an alkyl sulfoxide side chain. Bacillimide (1) and bacillapyrrole (2) exerted moderate (IC50 = 44.24 µM) and weak (IC50 = 190.45 µM) inhibitory effects on Candida albicans isocitrate lyase, respectively. Based on the growth phenotype using icl-deletion mutants and icl expression analyses, we determined that bacillimide (1) inhibits the transcriptional level of icl in C. albicans under C2-carbon-utilizing conditions. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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ISSN
- 1660-3397
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/42364
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DOI
- 10.3390/md20020138
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Bibliographic Citation
- Marine Drugs, v.20, no.2, 2022
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Publisher
- MDPI
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Keywords
- Streptomyces bacillaris; Bacillapyrrole; Bacillimide; Candida albicans; Isocitrate lyase
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Type
- Article
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Language
- English
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Document Type
- Article
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