Inhibitory Effects of Nitrogenous Metabolites from a Marine-Derived Streptomyces bacillaris on Isocitrate Lyase of Candida albicans SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Chung, Beomkoo | - |
dc.contributor.author | Hwang, Ji-Yeon | - |
dc.contributor.author | Park, Sung Chul | - |
dc.contributor.author | Kwon, Oh-Seok | - |
dc.contributor.author | Cho, Eunji | - |
dc.contributor.author | Lee, Jayho | - |
dc.contributor.author | Lee, Hyi Seung | - |
dc.contributor.author | Oh, Dong-Chan | - |
dc.contributor.author | Shin, Jongheon | - |
dc.contributor.author | Oh, Ki-Bong | - |
dc.date.accessioned | 2022-02-28T00:50:00Z | - |
dc.date.available | 2022-02-28T00:50:00Z | - |
dc.date.created | 2022-02-28 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/42364 | - |
dc.description.abstract | Two nitrogenous metabolites, bacillimide (1) and bacillapyrrole (2), were isolated from the culture broth of the marine-derived actinomycete Streptomyces bacillaris. Based on the results of combined spectroscopic and chemical analyses, the structure of bacillimide (1) was determined to be a new cyclopenta[c]pyrrole-1,3-dione bearing a methylsulfide group, while the previously reported bacillapyrrole (2) was fully characterized for the first time as a pyrrole-carboxamide bearing an alkyl sulfoxide side chain. Bacillimide (1) and bacillapyrrole (2) exerted moderate (IC50 = 44.24 µM) and weak (IC50 = 190.45 µM) inhibitory effects on Candida albicans isocitrate lyase, respectively. Based on the growth phenotype using icl-deletion mutants and icl expression analyses, we determined that bacillimide (1) inhibits the transcriptional level of icl in C. albicans under C2-carbon-utilizing conditions. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | Inhibitory Effects of Nitrogenous Metabolites from a Marine-Derived Streptomyces bacillaris on Isocitrate Lyase of Candida albicans | - |
dc.type | Article | - |
dc.citation.title | Marine Drugs | - |
dc.citation.volume | 20 | - |
dc.citation.number | 2 | - |
dc.contributor.alternativeName | 이희승 | - |
dc.identifier.bibliographicCitation | Marine Drugs, v.20, no.2 | - |
dc.identifier.doi | 10.3390/md20020138 | - |
dc.identifier.scopusid | 2-s2.0-85124724556 | - |
dc.identifier.wosid | 000762530100001 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | GLYOXYLATE CYCLE | - |
dc.subject.keywordPlus | PYRROLE | - |
dc.subject.keywordPlus | ALKALOIDS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | PERSISTENCE | - |
dc.subject.keywordPlus | PRODUCTS | - |
dc.subject.keywordPlus | ENZYME | - |
dc.subject.keywordAuthor | Streptomyces bacillaris | - |
dc.subject.keywordAuthor | Bacillapyrrole | - |
dc.subject.keywordAuthor | Bacillimide | - |
dc.subject.keywordAuthor | Candida albicans | - |
dc.subject.keywordAuthor | Isocitrate lyase | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |