Miharadienes A-D with unique cyclic skeletons from a marine-derived Streptomyces miharaensis
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Title
- Miharadienes A-D with unique cyclic skeletons from a marine-derived Streptomyces miharaensis
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Author(s)
- Choi, Byeoung Kyu; Cho, Duk-Yeon; Choi, Dong-Kug; Shin, Hee Jae
- KIOST Author(s)
- Shin, Hee Jae(신희재)
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Alternative Author(s)
- 최병규; 신희재
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Publication Year
- 2021-09-07
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Abstract
- A new type of natural products, miharadienes A-D (1-4), was isolated from the marine-derived Streptomyces miharaensis 151KO-143. Their structures were elucidated using a combination of NMR spectroscopy, acid hydrolysis, modified Mosher's method, electronic circular dichroism (ECD) and single crystal X-ray diffraction data. Interestingly, compounds 1 and 4 featured an unusual 2,10-dioxabicyclo[5.3.1]undecane ring system and a rare 5/5 furo[3,4-c]furan ring system, respectively, and all compounds 1-4 possessed a E,E-diene moiety at a side chain. Miharadiene D (4) exhibited moderate inhibitory effect of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglia cells.
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ISSN
- 2052-4129
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/42154
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DOI
- 10.1039/d1qo00773d
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Bibliographic Citation
- ORGANIC CHEMISTRY FRONTIERS, v.8, no.17, pp.4845 - 4852, 2021
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Publisher
- ROYAL SOC CHEMISTRY
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Subject
- NATURAL-PRODUCTS; FUTURE
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Type
- Article
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Language
- English
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Document Type
- Article
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