Polyketides and Meroterpenes from the Marine-Derived Fungi Aspergillus unguis 158SC-067 and A. flocculosus 01NT-1.1.5 and Their Cytotoxic and Antioxidant Activities
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Title
- Polyketides and Meroterpenes from the Marine-Derived Fungi Aspergillus unguis 158SC-067 and A. flocculosus 01NT-1.1.5 and Their Cytotoxic and Antioxidant Activities
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Author(s)
- ANH, CAO VAN; Kang, Jong Soon; Choi, Byeoung Kyu; Lee, Hwa Sun; Heo, Changsu; Shin, Hee Jae
- KIOST Author(s)
- Lee, Hwa Sun(이화선); Heo, Chang Su(허창수); Shin, Hee Jae(신희재)
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Alternative Author(s)
- Cao Van Anh; 최병규; 이화선; 허창수; 신희재
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Publication Year
- 2021-07
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Abstract
- Ten secondary metabolites, including a new grifolin analog, grifolin B (1); a new homovalencic acid derivative, 12-hydroxyhomovalencic acid (7); and a compound isolated from a natural source for the first time (9), along with seven known compounds, grifolin (2), averantin (3), 7-chloroaverantin (4), 1′-O-methylaverantin (5), 7-hydroxy-2-(2-hydroxypropyl)-5-pentylchromone (6), homovalencic acid (8), and bekeleylactone E (10), were isolated from two fungal strains. The structures of 1–10 were identified by detailed analysis and comparison of their spectroscopic data with literature values. Compounds 9 and 10 showed moderate cytotoxic activity against a panel of cancer cell lines (PC-3, HCT-15, MDA-MB-231, ACHN, NCI-H23, NUGC-3), with the GI50 values ranging from 1.1 µM to 3.6 µM, whereas 1 displayed a weak 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity without cytotoxicity against all tested cell lines.
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ISSN
- 1660-3397
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/41528
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DOI
- 10.3390/md19080415
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Bibliographic Citation
- MARINE DRUGS, v.19, no.8, pp.415 - 421, 2021
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Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
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Subject
- GRIFOLIN
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Keywords
- marine-derived fungi; Aspergillus sp; polyketides; meroterpenes; antioxidant; cytotoxicity
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Type
- Article
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Language
- English
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Document Type
- Article
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