The Synergistic Antibacterial Activity of 1-Acetyl-beta-Carboline and beta-Lactams Against Methicillin-Resistant Staphylococcus aureus (MRSA)
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Title
- The Synergistic Antibacterial Activity of 1-Acetyl-beta-Carboline and beta-Lactams Against Methicillin-Resistant Staphylococcus aureus (MRSA)
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Author(s)
- Shin, Hee Jae; Lee, Hyi-Seung; Lee, Dae-Sung
- KIOST Author(s)
- Shin, Hee Jae(신희재); Lee, Hyi Seung(이희승)
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Alternative Author(s)
- 신희재; 이희승
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Publication Year
- 2010-03
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Abstract
- 1-Acetyl-beta-carboline was isolated as an anti-MRSA agent from the fermentation broth of a marine actinomycete isolated from marine sediment. The producing strain was identified to be Streptomyces sp. by phylogenetic analysis of the 16S rRNA gene sequence. The anti-MRSA agent was isolated by bioactivity-guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and purification with a reversed-phase HPLC. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Combination of 1-acetyl-beta-carboline with ampicillin exhibited synergistic antibacterial activity against MRSA.
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ISSN
- 1017-7825
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/4135
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DOI
- 10.4014/jmb.0910.10019
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Bibliographic Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.20, no.3, pp.501 - 505, 2010
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Publisher
- KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
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Subject
- MECHANISMS
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Keywords
- Streptomyces sp 04DH52; anti-MRSA agent; 1-acetyl-beta-carboline
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Type
- Article
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Language
- English
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Document Type
- Article
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