The Synergistic Antibacterial Activity of 1-Acetyl-beta-Carboline and beta-Lactams Against Methicillin-Resistant Staphylococcus aureus (MRSA) SCIE SCOPUS KCI

Cited 38 time in WEB OF SCIENCE Cited 38 time in Scopus
Title
The Synergistic Antibacterial Activity of 1-Acetyl-beta-Carboline and beta-Lactams Against Methicillin-Resistant Staphylococcus aureus (MRSA)
Author(s)
Shin, Hee Jae; Lee, Hyi-Seung; Lee, Dae-Sung
KIOST Author(s)
Shin, Hee Jae(신희재)Lee, Hyi Seung(이희승)
Publication Year
2010-03
Abstract
1-Acetyl-beta-carboline was isolated as an anti-MRSA agent from the fermentation broth of a marine actinomycete isolated from marine sediment. The producing strain was identified to be Streptomyces sp. by phylogenetic analysis of the 16S rRNA gene sequence. The anti-MRSA agent was isolated by bioactivity-guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and purification with a reversed-phase HPLC. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Combination of 1-acetyl-beta-carboline with ampicillin exhibited synergistic antibacterial activity against MRSA.
ISSN
1017-7825
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4135
DOI
10.4014/jmb.0910.10019
Bibliographic Citation
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.20, no.3, pp.501 - 505, 2010
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
Subject
MECHANISMS
Keywords
Streptomyces sp 04DH52; anti-MRSA agent; 1-acetyl-beta-carboline
Type
Article
Language
English
Document Type
Article
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
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