Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase SCIE SCOPUS

Cited 41 time in WEB OF SCIENCE Cited 40 time in Scopus
Title
Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase
Author(s)
Lee, Yeon-Ju; Han, Yu-Ri; Park, Wanki; Nam, Seo-Hee; Oh, Ki-Bong; Lee, Hyi-Seung
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)
Publication Year
2010-12-01
Abstract
Guided by the inhibitory activities of indole-containing natural products against isocitrate lyase (ICL) from Candida albicans and sortase A (SrtA) from Staphylococcus aureus, a series of compounds structurally analogous to natural products were synthesized. Eight SrtA inhibitors and an ICL inhibitor having higher activities than the natural products were discovered by screening the enzyme inhibitory activities of synthesized compounds. Among the SrtA inhibitors discovered, six exhibited higher activities than p-hydroxymercuribenzoic acid, which suggests that these compounds have great potential as alternative antibacterial agents. (C) 2010 Elsevier Ltd. All rights reserved.
ISSN
0960-894X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3995
DOI
10.1016/j.bmcl.2010.10.029
Bibliographic Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.23, pp.6882 - 6885, 2010
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
STAPHYLOCOCCUS-AUREUS SORTASE; SURFACE-PROTEINS; LIBRARIES; 1,2,3,4-TETRAHYDRO-BETA-CARBOLINE; DERIVATIVES; ENZYME; SRTA
Keywords
Indole; beta-Carboline; Isocitrate lyase; Sortase A; Chemical library
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
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