Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase SCIE SCOPUS
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- Title
- Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase
- KIOST Author(s)
- Lee, Yeon Ju(이연주); Lee, Hyi Seung(이희승)
- Alternative Author(s)
- 이연주; 이희승
- Publication Year
- 2010-12-01
- Abstract
- Guided by the inhibitory activities of indole-containing natural products against isocitrate lyase (ICL) from Candida albicans and sortase A (SrtA) from Staphylococcus aureus, a series of compounds structurally analogous to natural products were synthesized. Eight SrtA inhibitors and an ICL inhibitor having higher activities than the natural products were discovered by screening the enzyme inhibitory activities of synthesized compounds. Among the SrtA inhibitors discovered, six exhibited higher activities than p-hydroxymercuribenzoic acid, which suggests that these compounds have great potential as alternative antibacterial agents. (C) 2010 Elsevier Ltd. All rights reserved.
- ISSN
- 0960-894X
- Bibliographic Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.23, pp.6882 - 6885, 2010
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Subject
- STAPHYLOCOCCUS-AUREUS SORTASE; SURFACE-PROTEINS; LIBRARIES; 1,2,3,4-TETRAHYDRO-BETA-CARBOLINE; DERIVATIVES; ENZYME; SRTA
- Keywords
- Indole; beta-Carboline; Isocitrate lyase; Sortase A; Chemical library
- Type
- Article
- Language
- English
- Document Type
- Article
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- There are no files associated with this item.
