Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase SCIE SCOPUS
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lee, Yeon-Ju | - |
| dc.contributor.author | Han, Yu-Ri | - |
| dc.contributor.author | Park, Wanki | - |
| dc.contributor.author | Nam, Seo-Hee | - |
| dc.contributor.author | Oh, Ki-Bong | - |
| dc.contributor.author | Lee, Hyi-Seung | - |
| dc.date.accessioned | 2020-04-20T08:25:13Z | - |
| dc.date.available | 2020-04-20T08:25:13Z | - |
| dc.date.created | 2020-01-28 | - |
| dc.date.issued | 2010-12-01 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/3995 | - |
| dc.description.abstract | Guided by the inhibitory activities of indole-containing natural products against isocitrate lyase (ICL) from Candida albicans and sortase A (SrtA) from Staphylococcus aureus, a series of compounds structurally analogous to natural products were synthesized. Eight SrtA inhibitors and an ICL inhibitor having higher activities than the natural products were discovered by screening the enzyme inhibitory activities of synthesized compounds. Among the SrtA inhibitors discovered, six exhibited higher activities than p-hydroxymercuribenzoic acid, which suggests that these compounds have great potential as alternative antibacterial agents. (C) 2010 Elsevier Ltd. All rights reserved. | - |
| dc.description.uri | 1 | - |
| dc.language | English | - |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
| dc.subject | STAPHYLOCOCCUS-AUREUS SORTASE | - |
| dc.subject | SURFACE-PROTEINS | - |
| dc.subject | LIBRARIES | - |
| dc.subject | 1,2,3,4-TETRAHYDRO-BETA-CARBOLINE | - |
| dc.subject | DERIVATIVES | - |
| dc.subject | ENZYME | - |
| dc.subject | SRTA | - |
| dc.title | Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase | - |
| dc.type | Article | - |
| dc.citation.endPage | 6885 | - |
| dc.citation.startPage | 6882 | - |
| dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.volume | 20 | - |
| dc.citation.number | 23 | - |
| dc.contributor.alternativeName | 이연주 | - |
| dc.contributor.alternativeName | 이희승 | - |
| dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.23, pp.6882 - 6885 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2010.10.029 | - |
| dc.identifier.scopusid | 2-s2.0-78149282878 | - |
| dc.identifier.wosid | 000283801400001 | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.subject.keywordPlus | STAPHYLOCOCCUS-AUREUS SORTASE | - |
| dc.subject.keywordPlus | SURFACE-PROTEINS | - |
| dc.subject.keywordPlus | LIBRARIES | - |
| dc.subject.keywordPlus | 1,2,3,4-TETRAHYDRO-BETA-CARBOLINE | - |
| dc.subject.keywordPlus | DERIVATIVES | - |
| dc.subject.keywordPlus | ENZYME | - |
| dc.subject.keywordPlus | SRTA | - |
| dc.subject.keywordAuthor | Indole | - |
| dc.subject.keywordAuthor | beta-Carboline | - |
| dc.subject.keywordAuthor | Isocitrate lyase | - |
| dc.subject.keywordAuthor | Sortase A | - |
| dc.subject.keywordAuthor | Chemical library | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
- Appears in Collections:
- Marine Resources & Environment Research Division > Marine Biotechnology &Bioresource Research Department > 1. Journal Articles
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