Alkylated phenanthrene distributions in black rockfish (Sebastes schlegelii) and biotransformation into hydroxylated metabolites after intragastric administration SCIE SCOPUS

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Title
Alkylated phenanthrene distributions in black rockfish (Sebastes schlegelii) and biotransformation into hydroxylated metabolites after intragastric administration
Author(s)
Ndabambi, M.; Kim, Ki Yong; Jung, Jee Hyun; Yim, Un Hyuk; Oh, Jeong-Eun
KIOST Author(s)
Jung, Jee Hyun(정지현)Yim, Un Hyuk(임운혁)
Publication Year
2021-03-25
Abstract
Marine organisms such as fish are at risk of exposure to petrogenic polycyclic aromatic hydrocarbons (PAHs) released in oil spills. PAH toxicities are affected by the rates of PAH biotransformation and elimination in fish tissues, but little information on these rates is available. In this study, the biotransformation and tissue distribution of methylated phenanthrenes-typical petrogenic PAHs found after oil spills-in black rockfish (Sebastes schlegelii) were investigated. Two groups of fish were used. Each fish in one group was given a single intragastric dose of 3-methylphenanthrene, and each fish in the other group was given a single intragastric dose of 3,6-dimethylphenanthrene. The fish were allowed to recover in purified sea water for 196 h. Methylated phenanthreneswere detected in only blood and liver for 24 h after dosing, but the concentrations decreased over time and > 98% had been eliminated by the end of the study. Four mono-hydroxylated metabolites of 3,6-dimethylphenanthrene and six mono-hydroxylated metabolites of 3-methylphenanthrene were tentatively identified for the first time from tandem mass spectrometry analyses of fish bile. The concentrations of these metabolites in bile remained constant for 192 h, suggesting that the metabolites could be used as biomarkers of rockfish exposure to petrogenic PAHs. (C) 2020 Elsevier B.V. All rights reserved.
ISSN
0048-9697
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/38778
DOI
10.1016/j.scitotenv.2020.143160
Bibliographic Citation
SCIENCE OF THE TOTAL ENVIRONMENT, v.762, 2021
Publisher
ELSEVIER
Subject
POLYCYCLIC AROMATIC-HYDROCARBONS; HORIZON OIL-SPILL; HEAVY CRUDE-OIL; HEMATOLOGICAL PARAMETERS; BIOMARKER RESPONSES; TOXICITY; FISH; BIOACCUMULATION; ACTIVATION; PAHS
Keywords
Methylphenanthrene; Hydroxylated methylphenanthrene; Cytochrome P450; Biotransformation; Biliary metabolites
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER
Related Researcher
Research Interests

Oil Spill Environmental Forensics,Persistent Organic Pollutants,Marine Aerosol,유류오염 환경법과학,지속성유기오염물질,해양 에어로졸

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